Results 31 to 40 of about 5,241 (198)

Haemoglobinopathy Awareness among Young Students in Turkey: Outcomes of a City-Wide Survey.

PLoS ONE, 2016
The success of prevention programs demonstrated the importance of raising awareness about haemoglobinopathies since the lack of knowledge and awareness about the disorders may serve as barriers to prevention, disclosure of disease status as well as to ...
Ramazan Azim Okyay, Özlem Çelenk, Ersin Nazlıcan, Muhsin Akbaba   +3 more
doaj   +1 more source

A systemic review of association between UDP glucuronosyltransferase family 1 member A1 (UGT1A1) polymorphisms in Gilbert's syndrome in Sickle Cell Disease

Journal of Clinical and Scientific Research, 2022
Gilbert's syndrome (GS) is a benign hereditary disorder of bilirubin metabolism due to a mutation in the UDP glucuronosyltransferase family 1 member A1 (UGT1A1) gene which results in hyperbilirubinaemia and related complications mainly cholelithiasis. It
Sanya Sachdeva, Ragini Bodade, Anand Bodade   +2 more
doaj   +1 more source

Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes

Nature Communications, 2016
Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization ...
Marek Cyrklaff, Sirikamol Srismith, Britta Nyboer, Kvetoslava Burda, Angelika Hoffmann, Felix Lasitschka, Sophie Adjalley, Cyrille Bisseye, Jacques Simpore, Ann-Kristin Mueller, Cecilia P. Sanchez, Friedrich Frischknecht, Michael Lanzer   +12 more
doaj   +1 more source

Risk factors for anaemia among Ghanaian women and children vary by population group and climate zone

Maternal and Child Nutrition, 2021
Anaemia has serious effects on human health and has multifactorial aetiologies. This study aimed to determine putative risk factors for anaemia in children 6–59 months and 15‐ to 49‐year‐old non‐pregnant women living in Ghana.
Nicolai Petry, James P. Wirth, Seth Adu‐Afarwuah, Rita Wegmuller, Bradley A. Woodruff, Sherry A. Tanumihardjo, Helena Bentil, William E.S. Donkor, Thomas N. Williams, Setareh Shahab‐Ferdows, Lilian Selenje, Abraham Mahama, Matilda Steiner‐Asiedu, Fabian Rohner   +13 more
doaj   +1 more source

Co-Inheritance of Haemoglobin D-Punjab and Beta Thalassemia - A Rare Variant [PDF]

Journal of Clinical and Diagnostic Research, 2017
Haemoglobinopathies are a frequent cause of anaemia in Northwestern India due to traditional practices of consanguineous marriages. Haemoglobin D-Punjab is one of the most common subvariants (55%) of haemoglobin D, which can be inherited as a homozygous
Kalyan Mansukhbhai Shekhda, Alpa C Leuva, Jyoti G Mannari, Aashka Vikas Ponda, Amee Amin   +4 more
doaj   +1 more source

Rheumatic Manifestations of Haemoglobinopathies

, 2018
Purpose of the Review: To provide a clinically useful literature review on the rheumatic manifestations of haemoglobinopathies, critically analysing the literature from the past 5 years.Recent Findings: There are limited new data to guide the management ...
Hughes, Michael; id_orcid
core   +1 more source

Clinico-Haematological Profile of Hereditary Haemolytic Anaemias in a Tertiary Health Care Hospital in South India [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Hereditary haemolytic anaemia is a common inherited disorder causing varying degree of morbidity and mortality. This includes disorders due to haemoglobin defect, membrane defect, and enzyme defect.
Chaitra Venkataswamy, AM Shanthala Devi
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2

Frontiers in Genome Editing, 2022
Sickle cell anaemia (SCA) is one of the common autosomal recessive monogenic disorders, caused by a transverse point mutation (GAG > GTG) at the sixth codon of the beta-globin gene, which results in haemolytic anaemia due to the fragile RBCs.
Anila George, Anila George, Nithin Sam Ravi, Nithin Sam Ravi, Kirti Prasad, Kirti Prasad, Lokesh Panigrahi, Lokesh Panigrahi, Sanya Koikkara, Vignesh Rajendiran, Vignesh Rajendiran, Nivedhitha Devaraju, Nivedhitha Devaraju, Joshua Paul, Aswin Anand Pai, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R. Velayudhan, Shaji R. Velayudhan, Alok Srivastava, Alok Srivastava, Kumarasamypet M. Mohankumar, Kumarasamypet M. Mohankumar   +26 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source