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A Scoring System for the Assessment of Quality of Care in the Management of Transfusion Dependent Thalassemia [PDF]

Hematology Reports
Objective: To identify criteria which can be used locally to assess the quality of care for thalassaemia patients, leading to quality improvement measures. In low-resource settings, there is often minimal support for services, and the investigations used
Michael Angastiniotis, Lily Cannon, Androulla Eleftheriou   +2 more
doaj   +2 more sources

Efficacy and safety of thalidomide in β-thalassaemia: a systematic review and meta-analysis [PDF]

Scientific Reports
Thalidomide has shown promise as an adjunct therapy for β-thalassaemia, yet its effectiveness and safety are uncertain. This systematic review and meta-analysis evaluate the efficacy and safety of thalidomide in β-thalassaemia; in both transfusion ...
Nirmani Yasara, Sajith Thilakarathne, K. D. C. Perera, Anuja Premawardhena, Sachith Mettananda   +4 more
doaj   +2 more sources

Serum erythropoietin and its determinants and associations in patients with haemoglobin E β-thalassaemia [PDF]

Scientific Reports
Erythropoietin is a hormone that stimulates erythropoiesis. The role of erythropoietin in the pathophysiology of HbE β-thalassaemia, a subtype of thalassaemia, is understudied.
Dinusha Amarasingha, Shiromi Perera, Anuja Premawardhena, Sachith Mettananda   +3 more
doaj   +2 more sources

The Outcomes of Patients with Haemoglobin Disorders in Cyprus: A Joined Report of the Thalassaemia International Federation and the Nicosia and Paphos Thalassaemia Centres (State Health Services Organisation)

Thalassemia Reports, 2022
Haemoglobinopathies, including thalassaemias and sickle-cell syndromes, are demanding, lifelong conditions that pose a significant burden to patients, families, and healthcare systems.
Michael Angastiniotis, Soteroula Christou, Annita Kolnakou, Evangelia Pangalou, Irene Savvidou, Dimitrios Farmakis, Androulla Eleftheriou   +6 more
doaj   +1 more source

TIF Standards for Haemoglobinopathy Reference Centres

Thalassemia Reports, 2022
Haemoglobin disorders are hereditary, lifelong and characterised by the need for multifaceted management. The question of quality in meeting standards of care that are likely to bring the best possible outcomes for patients is a necessary consideration ...
Michael Angastiniotis, Androulla Eleftheriou, Mohammed Naveed, Ali Al Assaf, Andreas Polynikis, Elpidoforos S. Soteriades, Dimitrios Farmakis   +6 more
doaj   +1 more source

Direct Chromosomal Phasing: An Easy and Fast Approach for Broadening Prenatal Diagnostic Applicability

Thalassemia Reports, 2022
The assignment of alleles to haplotypes in prenatal diagnostic assays has traditionally depended on family study analyses. However, this prevents the wide application of prenatal diagnosis based on haplotype analysis, especially in countries with ...
Stefania Byrou, George Christopoulos, Agathoklis Christofides, Christiana Makariou, Christiana Ioannou, Marina Kleanthous, Thessalia Papasavva   +6 more
doaj   +1 more source

Juggling between the Cost and Value of New Therapies: Does Science Still Serve Patient Needs?

Thalassemia Reports, 2023
Thalassaemia International Federation (TIF), representing the united voice of people with thalassaemia and their families globally, has been striving for more than three decades to empower research, by academic communities and industry, to focus on ...
Androulla Eleftheriou, Dimitrios Farmakis, Panos Englezos, Shobha Tuli, Elena Mylona, George Constantinou, Riyad Elbard, Saeed Jafaar Al-Awadhi, Sheikha Sheikha Bint Seif Al-Nahyan, Robert Ficarra, Michelle Abi Saad, Anton Skafi, Loris Angelo Brunetta, Fatemeh Hashemi, Eleni Michalaki, Abdul Baset Mohd Merdas, Michael Angastiniotis   +16 more
doaj   +1 more source

HBB Gene Mutations and Their Pathological Impacts on HbE/β-Thalassaemia in Kuala Terengganu, Malaysia

Diagnostics, 2023
Background: β-thalassaemia is a disorder caused by mutations in the β-globin gene, leading to defective production of haemoglobins (Hb) and red blood cells (RBCs). It is characterised by anaemia, ineffective erythropoiesis, and iron overload.
Hanan Kamel M. Saad, Wan Rohani Wan Taib, Azly Sumanty Ab Ghani, Imilia Ismail, Futoon Abedrabbu Al-Rawashde, Belal Almajali, Maysa Alhawamdeh, Alawiyah Awang Abd Rahman, Abdullah Saleh Al-wajeeh, Hamid Ali Nagi Al-Jamal   +9 more
doaj   +1 more source

Frequency of consanguineous marriage among the thalassaemia major patients in Bangabandhu Sheikh Mujib Medical University

Bangabandhu Sheikh Mujib Medical University Journal, 2022
Thalassaemia is a commonly occurring hereditary disorder. There is a high prevalence of thalassaemia disease in South-East Asia as well as Bangladesh. It is an autosomal recessive disorder, so consanguineous marriage is a very important factor for this ...
Nishat Mahzabin, Ismat Ara Islam, Mily Dey, Nusrat Jahan, Md Kamrul Hasan Sajib, Md Salahuddin Shah, Romana Chowdhury, Md Abdul Aziz, Amin Lutful Kabir   +8 more
doaj   +3 more sources

A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia

Scientific Reports, 2022
Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven.
Nirmani Yasara, Nethmi Wickramarathne, Chamila Mettananda, Ishari Silva, Nizri Hameed, Kumari Attanayaka, Rexan Rodrigo, Nirmani Wickramasinghe, Lakshman Perera, Aresha Manamperi, Anuja Premawardhena, Sachith Mettananda   +11 more
doaj   +1 more source