Results 51 to 60 of about 32,510 (254)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

In vitro activity of robenidine analogue NCL195 against methicillin-resistant Staphylococcus pseudintermedius

Microbiology Spectrum
The rise of difficult-to-treat infections among companion animals, particularly the increasing incidence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) in dogs poses significant challenges for effective treatment options in veterinary ...
Sayara Bista, Hang Thi Nguyen, Tatiana P. Soares da Costa, Lucy Woolford, Mark A. T. Blaskovich, Tania Veltman, Kelly A. Young, Adam McCluskey, Meng Siak, Stephen W. Page, Henrietta Venter, Darren J. Trott, Abiodun D. Ogunniyi   +12 more
doaj   +1 more source

The role of tocilizumab in the treatment of post‐transfusion hyperhaemolysis

eJHaem, 2023
Hyperhaemolysis syndrome (HHS) is a serious complication of transfusion mostly reported in patients with sickle cell disease. HHS is characterised by the destruction of both donor and autologous red blood cells.
Naeem Desai, Jayne Peters, Elizabeth Davies, Joseph Sharif   +3 more
doaj   +1 more source

Peculiarities in Changes of Peroxide Haemolysis of Erythrocytes in Patients with Generalized Periodontitis Combined with Iron Deficiency Anemia

, 2015
Introduction. Changes of peroxide resistance of erythrocytes as a reflection of the metabolic displacements, relating to the development of inflammation in the periodontal tissues can serve as an informative test for the assessment of the nature of ...
Slaba O.
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

RBC haemolysis assay.

, 2017
AAPH mediated RBC haemolysis assay to evaluate antioxidant status of a) N-IgG (■), OH•-IgG(◆), MG-IgG(▲) and OH•-MG-IgG(●). RBC alone (□) and RBC incubated with AAPH (o) served as positive and negative control.
Alok Raghav (3612926), Asif Ali (285640), Moin Uddin (789481), Sidra Islam (3612929), Farzana Khan (789482), Abdul Rouf Mir (789480), Khursheed Alam (285638)   +6 more
core   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Rsp promotes the transcription of virulence factors in an agr-independent manner in Staphylococcus aureus

Emerging Microbes and Infections, 2020
Staphylococcus aureus is a major human pathogen that causes a great diversity of community- and hospital-acquired infections. Rsp, a member of AraC/XylS family of transcriptional regulators (AFTRs), has been reported to play an important role in the ...
Banghui Liu, Baolin Sun
doaj   +1 more source

Precautionary Measures for Successful Open Heart Surgery in G6PD Deficient Patient- A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is among the most common enzymatic disorders of red blood cells. Cardiac surgeries on this group of individuals are associated with an additional risk in terms of impaired oxygenation, prolonged ...
RUPESH KUMAR
doaj   +1 more source