Results 71 to 80 of about 32,510 (254)

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Fatal acute haemolysis and methaemoglobinaemia in a man with renal failure and Alkaptonuria – Is nitisinone the solution?

Molecular Genetics and Metabolism Reports, 2020
Haemolysis and methaemoglobinaemia (MetHb) are rare metabolic complications that can occur in Alkaptonuria (AKU), for which there is no curative treatment.
A.S. Davison, E. Luangrath, E. Selvi, L.R. Ranganath   +3 more
doaj   +1 more source

Exercise-induced intravascular haemolysis in standardbred horses

, 2003
In human sports medicine a pathophysiological condition called 'sports anaemia' is reported. This condition has been attributed to episodes of intravascular haemolysis induced by physical exercise.
TEDESCHI D., SIGHIERI, CLAUDIO, BARAGLI, PAOLO, PELLEGRINI MASINI A., LUBAS, GEORGE   +4 more
core   +1 more source

Lifestyle behaviours are not associated with haemolysis: results from Donor InSight [PDF]

, 2020
BACKGROUND: Lifestyle behaviours such as physical activity, sedentary behaviour and dietary habits have been shown to influence blood lipid levels, and both lifestyle and blood lipids may be associated with haemolysis during storage of blood products. We
Hoekstra, Trynke; id_orcid, Hoekstra, Trynke, de Groot, Rosa, Lakerveld, Jeroen, de Korte, Dirk, Brug, Johannes, Lagerberg, Johan W, de Kort, Wim L A M, van den Hurk, Katja   +8 more
core   +2 more sources

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Haemolysis index for the screening of intravascular haemolysis: a novel diagnostic opportunity?

, 2018
The diagnostic approach to patients with intravascular haemolysis remains challenging, since no first-line laboratory test seems to be entirely suitable for the screening of this condition.
Franchini, Massimo, Favaloro, Emmanuel J, Lippi, Giuseppe   +2 more
core   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

A pilot study to assess serum potassium levels and haemolysis in red cell units [PDF]

, 2018
Introduction: Percentage of haemolysis is widely used as a quality parameter to assess red blood cell viability in blood banking. In certain blood banks, serum potassium level is used due to the unavailability of the former test. The relationship between
Mohd Fathullah, Tun Maizura, Seman, Zainina, Sarijan, Nurimatussolehah, Md Noor, Sabariah, Osman, Malina   +4 more
core   +3 more sources

Haemolysis during Sample Preparation Alters microRNA Content of Plasma [PDF]

, 2011
The presence of cell-free microRNAs (miRNAs) has been detected in a range of body fluids. The miRNA content of plasma/serum in particular has been proposed as a potential source of novel biomarkers for a number of diseases.
Michaela B Kirschner, Kao, S.C., Steven C Kao, Steven C. Kao, Vallely Michael P., Vallely, M.P., Glen Reid, J. James Edelman, Reid, G., Michael P Vallely, Edelman J. James, Nico van Zandwijk, Michaela B. Kirschner, Kirschner Michaela B., Armstrong Nicola J., Reid Glen, J James Edelman, van Zandwijk, N., Kirschner, M.B., Nicola J. Armstrong, Edelman, J.J., Armstrong, N.J., Nicola J Armstrong, Kao Steven C., Michael P. Vallely, van Zandwijk Nico   +25 more
core   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source