Results 201 to 210 of about 65,987 (236)

Breakthrough Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: Mechanistic Insights and Management Strategies

Transfusion, EarlyView.
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder caused by somatic mutations in the PIGA gene, resulting in loss of glycosylphosphatidylinositol (GPI)‐anchored proteins, including the complement regulatory proteins, CD55 and CD59.
Ganesh Raman, Meghana Vivek, Rida Hasan, Siobán Keel, Laura Connelly‐Smith   +4 more
wiley   +1 more source

Pretransfusion testing interference profile of IMC‐002: A novel anti‐CD47 monoclonal antibody engineered for minimized red cell binding

Transfusion, EarlyView.
Abstract Background CD47‐targeted agents can interfere with pretransfusion testing due to CD47 expression on red blood cells (RBCs). IMC‐002 is a novel anti‐CD47 human IgG4 monoclonal antibody engineered to minimize RBC binding; however, its interference profile during pretransfusion testing remains poorly characterized.
Tae‐Shin Kim, Jae Hyeon Park, Yousun Chung, Dae‐Hyun Ko, Seon Young Kim, Hyungsuk Kim   +5 more
wiley   +1 more source

Management of autoimmune haemolytic anaemia in low-to-middle income countries: current challenges and the way forward. [PDF]

Lancet Reg Health Southeast Asia
Datta SS, Berentsen S.
europepmc   +1 more source

Molecular characterization of CD36 deficiency in blood donors of Middle Eastern and African origin reveals transcript‐level defects beyond genomic variants

Transfusion, EarlyView.
Abstract Background The increasing diversity of blood donor populations has created new challenges for transfusion services worldwide. The identification of donors lacking relevant high‐prevalence antigens is becoming increasingly important to ensure compatible blood products for alloimmunized patients and to support the development of rare donor ...
Sarah Petermann, Inga Stellmacher, Brigitte K. Flesch, Tanja Rehling, Irina Häcker, Marc F. Schetelig, Alexander Carbol, Lambros Kordelas   +7 more
wiley   +1 more source

Implementation of soluble CD38 in blood crossmatching for patients on anti‐CD38 therapy: A single‐center experience

Transfusion, EarlyView.
Abstract Background Human monoclonal (MoAb) anti‐CD38 antibodies, such as daratumumab, are used to treat diseases such as multiple myeloma. Because red blood cells (RBCs) express CD38, these MoAbs interfere with antibody screening and crossmatching in blood banks.
Ayda Javanbakht, David Hanna, Grishma Amatya Jaspau, Ravi Sarode   +3 more
wiley   +1 more source

Identification of Lupus Erythematosus Cells and Ragocytes in Peripheral Blood from a Dog with Systemic Lupus Erythematosus

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 3‐year‐old female‐intact German Shepherd presented for the evaluation of progressive shifting leg lameness, carpal swelling, and weight loss with a poor appetite since adoption about three months prior. Routine blood smear evaluation, lymph node, and synovial fluid cytologies all revealed rare neutrophils with cytoplasmic inclusions ...
Samantha L. Braman, Jeremy P. Bessett, Katie L. Anderson, Kristen R. Friedrichs   +3 more
wiley   +1 more source

Case Report: T‐Lymphoblastic Leukemia in a Dog With Erythrophagia

Veterinary Clinical Pathology, EarlyView.
ABSTRACT A 2‐year‐old male German Shepherd dog was presented with progressive weight loss, lethargy, and hyporexia. Hematologic analysis revealed a moderate macrocytic normochromic anemia and moderate thrombocytopenia. Additionally, a pronounced leukocytosis was observed, characterized by 33% large lymphoid cells, marked neutrophilia with a significant
Francisca B. Lang, Matheus Y. dos Santos, Vinicius N. Hirata, Felipe A. B. de Sousa, Augusto de Oliveira, Lucas T. de Castro, Rafael A. Fighera, Alexandre Krause   +7 more
wiley   +1 more source

Laboratory Changes Supporting a Diagnosis of Immune‐Mediated Anemia in Cats With Initial Suspicion of Progressive Feline Leukemia Virus

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Progressive feline leukemia virus (FeLV) infection and anemia of suspected immune‐mediated origin (ASIMO) are associated with similar hematologic abnormalities, including anemia, neutropenia, and lymphocytosis. Cats with ASIMO may test positive for FeLV using point‐of‐care (POC) ELISA tests.
Nicholas Kelly, Katie McCallum, Will Bayton, Tyler Willard, Cassia Hare   +4 more
wiley   +1 more source