Results 41 to 50 of about 20,794 (210)

Exercise Programmes for People With Haemophilia: A Scoping Review. [PDF]

Haemophilia
ABSTRACT Background Advances in haemophilia treatment have enabled safe exercise practice as recommended by disease management guidelines, yet there is no gold‐standard protocol for optimal dose. Emerging therapies could influence exercise recommendations, highlighting the need for evidence‐based guidelines tailored to people with haemophilia to ensure
Veríssimo M, Kuhn T, Ricciardi J, Kosour C, Veríssimo M, Maia F, Ribeiro O, Gasparino RC.   +7 more
europepmc   +2 more sources

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

CATCH 2024 meeting summary: Collaborate & Address Treatment Challenges in Haemophilia

The Journal of Haemophilia Practice
Greater treatment choice and the associated flexibility in regimens has necessitated new conversations with people with haemophilia about their personal goals.
Christoforou Panagiotis, Smith Clive, McLaughlin Paul, Benson Gary, Cleary Janet, Jones Adam, Maissis Guy, Lester Will, Eales Marie, Harrison Cathy, Stephensen David, Larkin Niamh, McGowan Mark, Smith Mark, Topham Adam, Player Denise, Khair Kate   +16 more
doaj   +1 more source

Investigation of the Suitability of the ROTEM Assay to Measure Coagulation Potential in Blood From Patients on Concizumab Prophylaxis. [PDF]

Haemophilia
ABSTRACT Background Rotational thromboelastometry (ROTEM) aims to measure the coagulation potential in whole blood. Concizumab, an anti‐tissue factor pathway inhibitor (TFPI) antibody for prophylaxis in haemophilia, enhances tissue factor (TF)‐initiated coagulation by preventing inhibition of activated factor X (FXa), thus increasing thrombin ...
Eichler H, Butta NV, Riddell A, Augustsson C, Kjalke M, Jensen K, Paramo-Florencio A, Astermark J, Chowdary P, Jiménez-Yuste V.   +9 more
europepmc   +2 more sources

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

The experiences of people with haemophilia and their families of gene therapy in a clinical trial setting: regaining control, the Exigency study

Orphanet Journal of Rare Diseases, 2022
Background Gene therapy has the potential to change the life experience of people with haemophilia and family members. Few studies have sought to explore the impact of gene therapy on both individuals and families.
Simon Fletcher, Kathryn Jenner, Luke Pembroke, Michael Holland, Kate Khair   +4 more
doaj   +1 more source

Controlling the Field: Memory, Labor, and Ethics in Oral Histories of Brazilian Human Genetics

Berichte zur Wissenschaftsgeschichte, EarlyView.
This article examines how oral histories of twentieth‐century human genetics in Brazil reveal the politics of memory of fieldwork. Through a comparative analysis of interviews with prominent geneticist Francisco M. Salzano and technician Girley V. Simões, who worked with him for most of his career, this study explores the narrative strategies each ...
Rosanna Dent, Ana Carolina Vimieiro Gomes   +1 more
wiley   +1 more source

Plasma levels of IL-1β and IL-37 in patients with severe haemophilia

Journal of International Medical Research, 2020
Objective Haemophilia A and B are disorders caused by the lack of clotting factors VIII and IX, respectively. Repeated bleeding into the same joint leads to haemophilic arthropathy (HA).
Pei-Chin Lin, Shyh-Shin Chiou, Wan-Yi Hsu, Yu-Mei Liao, Shih-Pien Tsai, Hsiu-Lan Su, Ping-Tao Lu, Yu-Hsin Tseng   +7 more
doaj   +1 more source

Evolution of congenital haemophilia care in Taiwan

Journal of the Formosan Medical Association, 2022
Haemophilia care in Taiwan has come a long way over the past 35 years, from the absence of specialised haemophilia treatment centres before 1984 to the establishment of treatment centers in the majority of medical centers, the listing of haemophilia as a
Yeu-Chin Chen, Chia-Yau Chang, Shin-Nan Cheng, Ru-Yu Pan, Yu-Lueng Shih, Tsung-Ying Li, Sheng-Hao Wang   +6 more
doaj   +1 more source

florio HAEMO-A Digital Medical Device for Monitoring of Treatment, Symptoms and Physical Activities for People Living With Haemophilia. [PDF]

Haemophilia
ABSTRACT Introduction Despite therapeutic achievements in haemophilia care, there is still the need to monitor and define personal treatment outcomes and document results to achieve the best possible care. Hence, a need for unbiased, timely and comprehensive real‐world information exists to support informed shared decision‐making regarding treatment ...
Königs C, Astermark J, Blatny J, O Hara J, Iorio A, Negrier C, Peyvandi F, Steinitz K, Reininger AJ, Bonanad S.   +9 more
europepmc   +2 more sources