Safety and Use of Eptacog Beta 225 µg/kg in Patients With Haemophilia A or B With Inhibitors
Haemophilia, EarlyView.Introduction Eptacog beta is an activated recombinant human factor VII bypassing agent approved for treating bleeding episodes (BEs) in patients aged ≥12 years with haemophilia A or B with inhibitors. Two initial dose regimens (IDRs) of either 75 or 225 µg/kg, followed by 75 µg/kg, are approved.
Manuel Carcao +7 more
wiley +1 more source
Partial thromboplastin time test with kaolin: Normal range and modifications for the diagnosis of haemophilia and Christmas disease [PDF]
, 1965 Myrtle O. Matchett, G. I. C. Ingram
openalex +1 more source
Alternative Immunosuppression in Acquired Haemophilia A
Haemophilia, EarlyView.
Jayna Mistry +3 more
wiley +1 more source
Estimating the Factor VIII‐Equivalent Activity of Emicizumab Using Global Assays of Haemostasis
Haemophilia, EarlyView.ABSTRACT Background Emicizumab is a bispecific monoclonal antibody mimicking factor (F) VIII activity and an effective therapy for prophylaxis in people with haemophilia A (PWHA). The FVIII‐equivalent activity (FVIIIeq) of emicizumab remains unknown. Objectives To estimate FVIIIeq of emicizumab using global assays of haemostasis.
Daniel Kraemmer +6 more
wiley +1 more source
Radiological Stage of Hemophilic Arthropathy of Knee Does Not Correlate With Clinical Variables
Haemophilia, EarlyView.ABSTRACT Background Various functional and radiological systems have been developed to evaluate joint health and the severity of arthropathy in hemophilic patients. Clinical relevance of these radiological systems has received minimal attention. Methods Through a retrospective chart review, 84 patients with end‐stage hemophilic arthropathy of the knee ...
Arman Vahabi +4 more
wiley +1 more source
Blood and neoplastic diseases. Haemophilia and related disorders. [PDF]
, 1974 C. R. Rizza
openalex +1 more source
Spinal Stenosis: An Emerging Complication of Ageing in People With Haemophilia
Haemophilia, EarlyView.ABSTRACT Introduction Advances in haemophilia care have brought the challenges of ageing for people with haemophilia (PWH) to the forefront. Age‐related spinal degeneration may result in spinal stenosis; however, the rates in PWH are unknown. We sought to systematically review Irish PWH to address this gap in the current literature.
Claire Kelly +19 more
wiley +1 more source
Associations between coagulation factors, clinical phenotypes, cytokine profiles and polymorphisms in immune response genes of haemophilia A and B patients with and without inhibitors [PDF]
, 2010 MSc (Med) Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, 2009The underlying mechanism and determinants of inhibitor formation in approximately 30% haemophilia A and 5% haemophilia B patients are not fully
Ndlovu, Nontobeko Thenjiwe Lorraine
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