Results 241 to 250 of about 21,171,014 (388)

Balancing Promise and Peril: Hemophilia Gene Therapy Insights

open access: yesIUBMB Life, Volume 78, Issue 1, January 2026.
ABSTRACT Hemophilia is an inherited disorder characterized by impaired blood clotting caused by mutations in the genes responsible for producing coagulation factor (F) VIII (hemophilia A, HA) or FIX (hemophilia B, HB). Current treatment primarily relies on replacement therapy, involving frequent and costly infusions of FVIII or FIX concentrates.
Saicharan Akula   +4 more
wiley   +1 more source

Once‐weekly prophylactic treatment vs. on‐demand treatment with nonacog alfa in patients with moderately severe to severe haemophilia B [PDF]

open access: hybrid, 2016
Kaan Kavaklı   +8 more
openalex   +1 more source

Remarkable Prolongation of Irreversible APTT and Non‐Significant Hemorrhage: A Rare High Titer of FVIII Inhibitor Case Report and Literature Review

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 2, January 2026.
Patient with a bladder cancer history presented was diagnosed with Acquired hemophilia A (AHA) according to imaging findings and laboratory tests. The parameters returned to normal after treatment of methylprednisolone and cyclophosphamide. With the recurrence of AHA, the patient was finally confirmed to have liver metastases.
Ke‐Han Zhang   +4 more
wiley   +1 more source

Navigating the Transition From Adolescence to Adulthood Among Young People With Severe Haemophilia: The Qualitative Phase of the TRANSHEMO Project. [PDF]

open access: yesHaemophilia
Roques MA   +21 more
europepmc   +1 more source

Intra‐articular and intra‐osseous expanded adipose‐derived stromal cell injections for knee osteoarthritis‐related bone marrow lesions yield promising outcomes: Preliminary results in 16 athletes

open access: yesJournal of Experimental Orthopaedics, Volume 13, Issue 1, January 2026.
Abstract Purpose To explore the results of a fluoroscopic‐guided intra‐osseous (IO) and intra‐articular (IA) injection of expanded adipose‐derived stromal cells (ASCs) in athletes with bone marrow lesions (BML) associated with knee osteoarthritis (OA).
Miguel A. Khoury   +7 more
wiley   +1 more source

Outcomes in participants switching from FVIII replacement therapy to efanesoctocog alfa prophylaxis in XTEND-1: a post hoc analysis. [PDF]

open access: yesTher Adv Hematol
Susen S   +10 more
europepmc   +1 more source

Very low dislocation rate and good clinical outcome after Bereiter trochleoplasty and additional procedures following the Copenhagen patella–femoral instability algorithm: One‐ and two‐years outcomes from a consecutive cohort of 368 cases

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 1, Page 52-63, January 2026.
Abstract Purpose Patello–femoral instability (PFI) is often caused by predisposing factors, with trochlea dysplasia (TD) as the most prominent. Untreated patellar instability leads to impaired function and an increased risk of patellofemoral osteoarthritis.
Christian Dippmann   +4 more
wiley   +1 more source

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