Results 321 to 330 of about 21,171,014 (388)

Haemophilia imaging: a review

Skeletal Radiology, 2008
Haemophilia disorders are characterised by a blood coagulation anomaly leading to prolonged and excessive bleeding. Imaging provides an essential role in the investigation of both the musculoskeletal and the non-musculoskeletal complications of haemophilia. Our institution is home to a large tertiary referral centre for haemophilia treatment. Using our
Jody, Maclachlan, Antony, Gough-Palmer, Rikin, Hargunani, Joanna, Farrant, Brian, Holloway   +4 more
openaire   +2 more sources

Immune tolerance induction in paediatric patients with haemophilia A and inhibitors receiving emicizumab prophylaxis

Haemophilia, 2019
The formation of neutralizing antifactor VIII (fVIII) antibodies, called inhibitors, is the most common complication in modern haemophilia A care. Novel non‐factor replacement therapies, such as emicizumab, have sought to address the limitations of ...
G. Batsuli, K. Zimowski, Kelly Tickle, S. Meeks, R. Sidonio   +4 more
semanticscholar   +1 more source

Management of patients with severe haemophilia a without inhibitors on prophylaxis with emicizumab: AICE recommendations with focus on emergency in collaboration with SIBioC, SIMEU, SIMEUP, SIPMeL and SISET

Haemophilia, 2020
The factor VIII (FVIII)‐mimetic bispecific monoclonal antibody, emicizumab, previously approved for prophylaxis in haemophilia A with inhibitors, has been recently licensed in several countries also in patients with severe haemophilia A (PWSHA) without ...
A. Coppola, G. Castaman, R. Santoro, M. Mancuso, M. Franchini, R. Marino, G. Rivolta, C. Santoro, E. Zanon, L. Sciacovelli, S. Manca, R. Lubrano, M. Golato, A. Tripodi, A. Rocino   +14 more
semanticscholar   +1 more source

Is haemophilia B less severe than haemophilia A?

Haemophilia, 2013
SummaryA number of observations suggest that severe factor IX deficiency (<1%) may be less clinically severe than the corresponding factor VIII deficiency: (i) Less factor consumption. There is evidence that patients with haemophilia B (HB) consume yearly less FIX for replacement therapy than patients with haemophilia (HA).
P M, Mannucci, M, Franchini
openaire   +2 more sources

Acquired haemophilia A

Blood Coagulation & Fibrinolysis, 1998
The distinction between a specific factor inactivator and a non-specific inhibitor is important when confronted by a patient with a history of bleeding and abnormal in-vitro coagulation tests. We report on two patients who presented with bleeding and a prolonged activated partial thromboplastin time.
M A, Kazmi, W, Pickering, M P, Smith, L J, Holland, G F, Savidge   +4 more
openaire   +2 more sources

Liver transplantation and haemophilia A

Journal of Hepatology, 1995
Liver transplantation has become the standard treatment for a variety of inherited metabolic disorders. We report on two patients who underwent successful transplantation for posthepatitis viral cirrhosis, which developed following blood factor replacement for haemophilia A.
J P, Lerut, P F, Laterre, E, Lavenne-Pardonge, M, Donataccio, A, Geubel, M S, Reynaert, J B, Otte   +6 more
openaire   +2 more sources

Oral isotretinoin and haemophilia A

Journal of the European Academy of Dermatology and Venereology, 2004
ABSTRACTThe effects of oral isotretinoin on the coagulation system are still not well known: some case reports describe thrombocytopenia or thrombocytosis, others present different effects on fibrinolysis. We report a case of severe acne treated with oral isotretinoin in a patient affected with haemophilia A.
BETTOLI V, PIZZIGONI S, VASINA S, MANCINO A, VIRGILI, Anna   +4 more
openaire   +3 more sources

Genetic engineering for haemophilia A

Expert Opinion on Biological Therapy, 2006
At first sight, haemophilia A would appear to be an ideal candidate for treatment by gene therapy. There is a single gene defect; cells in different parts of the body, but especially the liver, produce Factor VIII, and only 5% of normal levels of Factor VIII are necessary to prevent the serious symptoms of bleeding.
Shu Uin, Gan, Oi Lian, Kon, Roy Y, Calne
openaire   +2 more sources

Bleeding and safety outcomes in persons with haemophilia A without inhibitors: Results from a prospective non‐interventional study in a real‐world setting

Haemophilia, 2019
Prospectively collected real‐world data on bleeds, haemophilia treatment and safety in persons with haemophilia A (PwHA) without factor VIII (FVIII) inhibitors are limited.
R. Kruse-Jarres, J. Oldenburg, E. Santagostino, M. Shima, C. Kempton, C. Kessler, M. Lehle, S. Chebon, Nives Selak Bienz, E. Asikanius, J. Mahlangu   +10 more
semanticscholar   +1 more source

Spontaneous Haemophilia in a Female

Thrombosis and Haemostasis, 1960
SummaryA case of haemophilia in a young white girl is described. There was a history of bleeding from birth. The thromboplastin generation test was grossly abnormal and A. H. G. levels were below 1%. Bleeding time and capillary morphology was within normal limits.
E H, BRAUN, D B, STOLLAR
openaire   +2 more sources