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Haemophilia, 2019
A significant fraction of women with an impaired factor VIII or IX gene in the X chromosome, carriers of haemophilia, will have clotting factor activities corresponding to those seen in males with non‐severe haemophilia, hence, experience an increased ...
M. Osooli +6 more
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A significant fraction of women with an impaired factor VIII or IX gene in the X chromosome, carriers of haemophilia, will have clotting factor activities corresponding to those seen in males with non‐severe haemophilia, hence, experience an increased ...
M. Osooli +6 more
semanticscholar +1 more source
Vnitrni lekarstvi, 2012
Acquired haemophilia A is a rare auto-immune disease caused by an inhibitory antibody to factor VIII. Patients with this disorder are at high risk of severe bleeding until the inhibitor has been eradicated. Management of this disorder consists in rapid accurate diagnosis, control of bleeding and eradication of the inhibitor by immunosuppression.
P, Smejkal +3 more
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Acquired haemophilia A is a rare auto-immune disease caused by an inhibitory antibody to factor VIII. Patients with this disorder are at high risk of severe bleeding until the inhibitor has been eradicated. Management of this disorder consists in rapid accurate diagnosis, control of bleeding and eradication of the inhibitor by immunosuppression.
P, Smejkal +3 more
openaire +1 more source
Haemophilia, 2018
1 . Franchini M , Coppola A , Tagliaferri A , Lippi G . FEIBA versus NovoSeven in hemophilia patients with inhibitors . Semin Thromb Hemost . 2013 ; 39 ( 7 ): 772 778 . 2 . Takedani H , Shima M , Horikoshi Y , et al.
J. Jayakar +6 more
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1 . Franchini M , Coppola A , Tagliaferri A , Lippi G . FEIBA versus NovoSeven in hemophilia patients with inhibitors . Semin Thromb Hemost . 2013 ; 39 ( 7 ): 772 778 . 2 . Takedani H , Shima M , Horikoshi Y , et al.
J. Jayakar +6 more
semanticscholar +1 more source
Management of acquired haemophilia A
Hämostaseologie, 2015SummaryAcquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder.
A, Tiede +3 more
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Thrombosis and Haemostasis, 1962
SummaryA 6 year old girl with symptoms of severe haemophilia and a haemophilia B factor B content of 2%—3% of normal is described. Investigation of the family revealed that the mother and the sister of the girl were carriers of the haemophilia B gene, while the father was normal. Chromosome studies showed a pattern of 2 X chromosomes.
J E, NILEHN, I M, NILSSON
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SummaryA 6 year old girl with symptoms of severe haemophilia and a haemophilia B factor B content of 2%—3% of normal is described. Investigation of the family revealed that the mother and the sister of the girl were carriers of the haemophilia B gene, while the father was normal. Chromosome studies showed a pattern of 2 X chromosomes.
J E, NILEHN, I M, NILSSON
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Mutation Profiling in Haemophilia A
Thrombosis and Haemostasis, 2001SummaryHaemophilia A is a X-linked recessive bleeding disorder caused by deficiency or absence of coagulation factor VIII (FVIII) due to heterogeneous defects in the FVIII gene. The large size of the FVIII gene (26 exons spanning 186 kb) has hampered mutation analysis for many years.
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Haemophilia, 2018
Persons with haemophilia (PWH) experience recurrent joint bleeding which leads from early synovitis to irreversible joint damage. Pain strongly affects patients’ quality of life, as PWH suffer from acute pain associated with haemarthroses and chronic ...
A. Tagliaferri +5 more
semanticscholar +1 more source
Persons with haemophilia (PWH) experience recurrent joint bleeding which leads from early synovitis to irreversible joint damage. Pain strongly affects patients’ quality of life, as PWH suffer from acute pain associated with haemarthroses and chronic ...
A. Tagliaferri +5 more
semanticscholar +1 more source
Nederlands tijdschrift voor geneeskunde, 1997
A 74-year-old man developed a severe bleeding disorder on the basis of acquired Factor VIII (F VIII) inhibitor. Coagulation assays showed a prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT);F VIII level was 0.07 IU and F VIII inhibitor level 8.8 Bethesda units (BU).
R E, Brouwer +3 more
openaire +1 more source
A 74-year-old man developed a severe bleeding disorder on the basis of acquired Factor VIII (F VIII) inhibitor. Coagulation assays showed a prolonged activated partial thromboplastin time (APTT) with a normal prothrombin time (PT);F VIII level was 0.07 IU and F VIII inhibitor level 8.8 Bethesda units (BU).
R E, Brouwer +3 more
openaire +1 more source