Results 91 to 100 of about 1,682,610 (304)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

The social context in bark beetle – fungus bioassays: a case study in European fir engraver bark beetles and their fungal associates

open access: yesFrontiers in Microbiology
BackgroundCertain species of bark beetles (Curculionidae: Scolytinae) are among the most aggressive herbivorous forest insects due to their mass aggregation behavior and symbiosis with filamentous fungi.
Sifat Munim Tanin   +2 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

An ex vivo comparison of the tensile strengthening properties of protein derivatives on damaged hair [PDF]

open access: yes, 2015
Conventional conditioning agents, cationic surfactants and polymers, are often limited in their ability to repair and strengthen the hair fibre, while protein-derived actives have been found to enhance the tensile strength of damaged hair.
Daniels, Gabriela   +3 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Adipose Tissue‐Derived Exosomes in the Treatment of Lichen Planopilaris: A Case Report

open access: yesClinical Case Reports
Adipose‐derived exosomes may offer a novel therapeutic approach for lichen planopilaris (LPP) unresponsive to standard treatments, with preliminary evidence suggesting potential benefits in symptom control and hair preservation.
Mohammad Ali Nilforoushzadeh   +4 more
doaj   +1 more source

Next-Gen orientation: supporting international students with generative AI NPCs in VR

open access: yesFrontiers in Computer Science
Educational Virtual Reality (VR) provides immersive learning environments, yet most contemporary applications rely on pre-scripted Non-Player Characters (NPCs) that offer limited personalization and rigid interaction paths.
Santiago Berrezueta-Guzman   +1 more
doaj   +1 more source

A no-short scalar hair theorem for rotating Kerr black holes

open access: yes, 2016
If a black hole has hair, how short can this hair be? A partial answer to this intriguing question was recently provided by the 'no-short hair' theorem which asserts that the external fields of a spherically-symmetric electrically neutral hairy black ...
Hod, Shahar
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Exploiting the Kumaraswamy distribution in a reinforcement learning context

open access: yesFrontiers in Robotics and AI
Mini cranes play a pivotal role in construction due to their versatility across numerous scenarios. Recent advancements in Reinforcement Learning (RL) have enabled agents to operate cranes in virtual environments for predetermined tasks, paving the way ...
Davide Picchi, Sigrid Brell-Çokcan
doaj   +1 more source

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