Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model
Advanced Science, EarlyView.A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen +15 more
wiley +1 more source
Fro Hair to Eternity - ACE237.2
Examples of black people’s hair styles. Benin bronzes. Commentary talks of Africans as the original hairdressers. Photographs of African and Afro-Caribbean women.
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Hitting pause on chemotherapy-induced alopecia: transient p53 activation as a guardian of the hair follicle. [PDF]
J Clin InvestLi EB, Klay M, Yi R.
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo +14 more
wiley +1 more source
Hair cortisol concentrations to picture the dysregulation of the hypothalamic-pituitary-adrenocortical axis in panic disorder. [PDF]
Sci RepPetrowski K +4 more
europepmc +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Localized Infrared Hyperthermia as an Adjunctive Therapy for Long-Standing Hailey-Hailey Disease: A Case Report. [PDF]
Clin Cosmet Investig DermatolWu H +5 more
europepmc +1 more source
Advanced Science, EarlyView.The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li +4 more
wiley +1 more source
Case Report: A case of Rothmund-Thomson syndrome-like phenotype with an <i>ANAPC1</i> variant of uncertain significance and observed hair improvement. [PDF]
Front Med (Lausanne)Huang C, Liu Q, Yang D.
europepmc +1 more source
Advanced Science, EarlyView.Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang +21 more
wiley +1 more source