Results 231 to 240 of about 448,670 (343)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Efficacy of Local and Whole-Body Phototherapy for the Treatment of Various Types of Alopecia Areata. [PDF]

Photodermatol Photoimmunol Photomed
Yamamoto A, Enomoto Y, Sakurai M, Watanabe O, Sakaida T, Kanayama Y, Morita A.   +6 more
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Case Report: Successful treatment of pediatric alopecia universalis with ritlecitinib after failure of baricitinib. [PDF]

Front Med (Lausanne)
Lv X, Chen Y, Ruan SF, Xu Q, Mao J, Zhu L, Xia W, Bao S, Zhuang Z, Chen L, Cheng B, Ji C.   +11 more
europepmc   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses. [PDF]

Biomolecules
Feng Y, Wu J, Tang H, Liu S, Jia H, Liang Y, Li Z, Li L, Li L, Lei X.   +9 more
europepmc   +1 more source

Rare variant of ankyloblepharon-ectodermal defect-cleft lip/cleft palate syndrome: Curly hair-ankyloblepharon-nail disease syndrome

, 2018
Debdeep Mitra, Ajay Chopra, Renu Kandpal, Reetu Agarwal   +3 more
openalex   +2 more sources

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Epidemiology and burden of alopecia areata in Taiwan: a systematic review. [PDF]

Front Med (Lausanne)
Yang CC, Ma SH, Yen PJ, Lin HW, Chen KA, Chen CC.   +5 more
europepmc   +1 more source

Disease risk analysis for the reintroduction of the short-haired bumblebee (Bombus subterraneus) to the UK

, 2016
Rebecca Vaughan‐Higgins, A. W. Sainsbury, Katie M. Beckmann, Mark J. F. Brown   +3 more
openalex   +1 more source