Results 101 to 110 of about 441,676 (302)

The GPR30 agonist G-1 promotes hair growth via Wnt/Hedgehog signaling in mice

Frontiers in Pharmacology
BackgroundGPR30 is a membrane-associated receptor involved in rapid, non-genomic estrogen signaling. Estrogen significantly influences hair growth and susceptibility to hair loss, with differences primarily driven by hormonal factors.
Mayu Yamano, Yuto Yamanaka, Shota Nishikawa, Yuki Masujima, Ryuji Ohue-Kitano, Ikuo Kimura, Ikuo Kimura, Ikuo Kimura   +7 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Functional anatomy of the hair follicle: The Secondary Hair Germ

Experimental Dermatology, 2018
The secondary hair germ (SHG)—a transitory structure in the lower portion of the mouse telogen hair follicle (HF)—is directly involved in anagen induction and eventual HF regrowth.
A. Panteleyev
semanticscholar   +1 more source

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Effects of UV Induced-Photoaging on the Hair Follicle Cycle of C57BL6/J Mice

Clinical, Cosmetic and Investigational Dermatology, 2021
Xu Zhai,1 Meihua Gong,1,2 Yixuan Peng,1 Daping Yang1 1Department of Plastic Surgery, The 2nd Hospital of Harbin Medical University, Harbin, People’s Republic of China; 2Department of Plastic and Cosmetic Surgery, Shenzhen People’s Hospital ...
Zhai X, Gong M, Peng Y, Yang D
doaj  

Hair Growth Promoting Effect of Urticadioica L

Central Asian Journal of Medical Sciences, 2018
Objectives: We investigated the effect of Urticadioica L extracts on hair growth by using in-vitro and ex vivo study methods. Methods: Human single hair follicle and dermal papilla cells obtained from scalp skin samples of healthy volunteers.
Khaliun Myagmar, Enkhsaikhan Lkhagvasuren, Munkhbayar Semchin   +2 more
doaj   +1 more source

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Nature Communications, 2017
Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen–anagen transition (TAT) around the ...
Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, M. Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huan-huan Jia, Yu'e Wu, Jia Liu, S. Nedospasov, E. Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu   +24 more
semanticscholar   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

Journal of Developmental Biology, 2017
The epidermis is the outermost layer of the skin and provides a protective barrier against environmental insults. It is a rapidly-renewing tissue undergoing constant regeneration, maintained by several types of stem cells.
Y. Abe, N. Tanaka
semanticscholar   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source