Results 41 to 50 of about 441,676 (302)
Cells, 2019 The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue ...
P. Gentile, S. Garcovich
semanticscholar +1 more source
The dermal sheath: An emerging component of the hair follicle stem cell niche
Experimental Dermatology, 2020 Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle ...
P. Martino, N. Heitman, Michael Rendl
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Bioengineering of Hair Follicle-like Structure for Validation of Hair Growth Promoting Compounds
Bioengineering, 2022 We aimed to establish screening and efficacy test techniques for use in the development of hair-promoting agents. To this end, we used the dermal papilla cell (DPc)-derived immortalized cell line (SV40T-hTERT DPc) and neonatal foreskin-derived ...
Hyun Woo Joo +3 more
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An updated classification of hair follicle morphogenesis
Experimental Dermatology, 2019 Hair follicle (HF) formation in developing embryonic skin requires stepwise signalling between the epithelial epidermis and mesenchymal dermis, and their specialized derivatives, the placode/germ/peg and dermal condensate/papilla, respectively ...
Nivedita Saxena +2 more
semanticscholar +1 more source
SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice
EMBO Journal, 2020 Hair follicle stem cells (HFSCs) are maintained in a quiescent state until activated to grow, but the mechanisms that reactivate the quiescent HFSC reservoir are unclear.
Guo Li +12 more
semanticscholar +1 more source
Journal of Investigative Dermatology, 1993 Proteoglycans are polymorphic macromolecules present in all mammalian tissues, including the skin and its appendages. They consist of a core protein to which one or more glycosaminoglycan chains are covalently attached. Broadly, they can be divided into classes based on location and core protein structure.
openaire +2 more sources
Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration
Experimental and Molecular MedicineHair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles.
Jung Hyun Lee, Sekyu Choi
semanticscholar +1 more source
Cell Stem Cell, 2019 Hair growth can be induced from resting mouse hair follicles by topical application of JAK inhibitors, suggesting that JAK-STAT signaling is required for maintaining hair follicle stem cells (HFSCs) in a quiescent state.
E. Wang +4 more
semanticscholar +1 more source
The role of the microbiome in scalp hair follicle biology and disease
Experimental Dermatology, 2019 The skin surface microbiome and its role in skin diseases have received increasing attention over the past years. Beyond, there is evidence for a continuous exchange with the cutaneous immune system in healthy skin, where hair follicles (HFs) provide ...
Katarzyna Polak-Witka +3 more
semanticscholar +1 more source
Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome
CellsThe hair follicle is a complex of mesenchymal and epithelial cells acquiring different properties and characteristics responsible for fulfilling its inductive and regenerative role.
Ons Ben Hamida +4 more
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