Results 131 to 140 of about 213,913 (308)
Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source
Frontiers in MedicineIntroductionHair transplantation is a therapeutic option for androgenic alopecia (AGA) with visible results after 1 year. Post-transplant care may aid graft survival and growth, though few studies have assessed its efficacy.
Daniel Ortega Quijano +6 more
doaj +1 more source
Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model
Advanced Science, EarlyView.A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen +15 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo +14 more
wiley +1 more source
Sustainable management of tannery hair waste through composting
Bovine hair, resulting from the unhairing of hides and skins, forms a major component of tannery solid wastes that is often disposed to landfill.
Onyuka, Arthur
core
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Application of Non-Pharmacologic Therapy in Hair Loss Treatment and Hair Regrowth
Xinlyu Huang,1 Pengxiang Zhao,2 Gongjie Zhang,1 Xiangxi Su,1 Hanlin Li,1 Huizi Gong,1 Xuemei Ma,2 Fang Liu1 1Department of Dermatology, Venereology and Cosmetology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of ...
Zhang G +7 more
core
Advanced Science, EarlyView.The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li +4 more
wiley +1 more source
Advanced Science, EarlyView.Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang +21 more
wiley +1 more source