Results 71 to 80 of about 846,397 (361)

Aminoglycoside ototoxicity and hair cell ablation in the adult gerbil: A simple model to study hair cell loss and regeneration [PDF]

, 2015
The Mongolian gerbil, Meriones unguiculatus, has been widely employed as a model for studies of the inner ear. In spite of its established use for auditory research, no robust protocols to induce ototoxic hair cell damage have been developed for this ...
Abrashkin, Alam, Aran, Astbury, Bae, Bichler, Boettcher, Brown, Brummett, Brummett, Brummett, Burkard, Chen, Chen, Chole, Dai, Dodson, Ghorayer, Hallworth, Hellier, Henry, Henzl, Hirose, Hirose, Huizing, Hurley, Khimich, Knirsch, Koitchev, Kong, Lang, Leake, Leila Abbas, Linthicum, MacDonald, Marcelo N. Rivolta, Mathog, Matz, May, McFadden, McGuirt, McLean, Millard, Mills, Murillo-Cuesta, Nadol, Oesterle, Oesterle, Otto, Poirrier, Polgar, Raphael, Saha, Schmiedt, Schuknecht, Sheppard, Silverstein, Sone, Stankovic, Sugawara, Suryadevara, Tannenbaum, Taylor, Taylor, van Loon, Versnel, Wanamaker, Wanamaker, Wang, Wang, Webster, Yang, Ylikoski, Zilberstein   +73 more
core   +1 more source

Quantification and dosimetric impact of intra‐fractional bladder changes during CBCT‐guided online adaptive radiotherapy for pelvic cancer treatments

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study quantitatively evaluates bladder changes and their dosimetric impact during the on‐couch adaptive process on a commercial CBCT‐based online adaptive radiotherapy (CT‐gART) platform. Methods Data from 183 fractions of ten patients receiving online ART for pelvic cancers were analyzed retrospectively.
Ingrid Valencia Lozano, Elizabeth Buss, Catherine S. Spina, David P. Horowitz, Lisa A. Kachnic, Michael Price, Yi‐Fang Wang, Reshma Munbodh   +7 more
wiley   +1 more source

Scalp Cooling in Daily Clinical Practice for Breast Cancer Patients Undergoing Curative Chemotherapy: A Multicenter Interventional Study

Asia-Pacific Journal of Oncology Nursing, 2019
Objective: Chemotherapy-induced alopecia is a common and distressful side effect, especially among breast cancer patients. Scalp cooling (SC) can reduce hair loss during anthracycline- and taxane-based chemotherapy.
Emilia Gianotti, Giorgia Razzini, Manuela Bini, Caterina Crivellaro, Angela Righi, Simona Darecchio, Stefania Lui, Maria Laura Basiricò, Silvia Cocconi, Katia Cagossi, Alessia Ferrari, Fabrizio Artioli   +11 more
doaj   +1 more source

The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the inner ear [PDF]

, 1999
After noise- or drug-induced hair-cell loss, the sensory epithelia of the avian inner ear can regenerate new hair cells. Few molecular markers are available for the supporting-cell precursors of the hair cells that regenerate, and little is known about ...
Cotanche, Douglas A, Goodyear, Richard J, Kruger, Robert P, Legan, P Kevin, Raphael, Yehoash, Richardson, Guy P, Warchol, Mark E   +6 more
core   +2 more sources

Open‐source deep‐learning models for segmentation of normal structures for prostatic and gynecological high‐dose‐rate brachytherapy: Comparison of architectures

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The use of deep learning‐based auto‐contouring algorithms in various treatment planning services is increasingly common. There is a notable deficit of commercially or publicly available models trained on large or diverse datasets containing high‐dose‐rate (HDR) brachytherapy treatment scans, leading to poor performance on images ...
Andrew J. Krupien, Yasin Abdulkadir, Dishane C. Luximon, John Charters, Huiming Dong, Jonathan Pham, Dylan O'Connell, Jack Neylon, James M. Lamb   +8 more
wiley   +1 more source

Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells [PDF]

, 2017
Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells.
Edge, Albert S.B., Karp, Jeffrey M., Langer, Robert S, Lenz, Danielle R., Lu, Lin, McLean, Dalton, McLean, Will J., Yin, Xiaolei   +7 more
core   +2 more sources

Advantages and limitations of navigation‐based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard, Simon J. P. Meara, Ehab M. Ibrahim, Carl G. Rowbottom   +3 more
wiley   +1 more source

Spherical collapse in scalar-Gauss-Bonnet gravity: taming ill-posedness with a Ricci coupling [PDF]

arXiv, 2023
We study spherical collapse of a scalar cloud in scalar-Gauss-Bonnet gravity - a theory in which black holes can develop scalar hair if they are in a certain mass range. We show that an additional quadratic coupling of the scalar field to the Ricci scalar can mitigate loss of hyperbolicity problems that have plagued previous numerical collapse studies ...
arxiv  

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]

, 2005
The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia, Braig, Claudia, Engel, Jutta, Hirt, Bernhard, Knipper, Marlies, Knirsch, Martina, Köpschall, Iris, Langer, Patricia, Müller, Marcus, Münkner, Stefan, Pfaff, Imke, Pfister, Markus, Rohbock, Karin, Ruth, Peter, Rüsch, Alfons, Rüttiger, Lukas, Sausbier, Matthias, Winter, Harald, Zimmermann, Ulrike   +18 more
core  

Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion [PDF]

, 2002
The desmoglein compensation hypothesis, namely that one desmoglein can compensate for loss of function of another, has been proposed to explain the tissue specificity of the autoantibody-induced loss of cell adhesion in pemphigus.
Hanakawa, Yasushi, Matsuyoshi, Norihisa, Stanley, John R.   +2 more
core   +1 more source