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Clinical Lymphoma and Myeloma, 2009
Progress in the treatment of patients with hairy cell leukemia (HCL) has led to a significant change in the natural history of the disease. With current regimens, the majority of patients achieve a complete remission, and their survival curves are similar to those for appropriate age-matched individuals without the disease.
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Progress in the treatment of patients with hairy cell leukemia (HCL) has led to a significant change in the natural history of the disease. With current regimens, the majority of patients achieve a complete remission, and their survival curves are similar to those for appropriate age-matched individuals without the disease.
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Surface immunoglobulins on hairy cells of 55 patients with hairy cell leukemia
American Journal of Hematology, 1982AbstractSurface immunoglobulins (SIg) were determined on peripheral blood samples from 55 patients with hairy cell leukemia (HCL) and on hairy cells from spleen preparations of 14 of these 55 patients. The patterns of SIg for HCL was compared to the patterns on peripheral blood leukemic cells from 39 patients with chronic lymphocytic leukemia (CLL) and
H M, Golomb +3 more
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Leukemia Research, 1987
A mother and son are reported who both developed hairy cell leukemia. The mother aged 74 presented with pancytopenia and responded well to splenectomy. Four years later her son aged 48 presented with pancytopenia; splenectomy was less effective but he improved after treatment with interferon-alpha. Histological examination of the splenic tissue in both
C G, Begley +5 more
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A mother and son are reported who both developed hairy cell leukemia. The mother aged 74 presented with pancytopenia and responded well to splenectomy. Four years later her son aged 48 presented with pancytopenia; splenectomy was less effective but he improved after treatment with interferon-alpha. Histological examination of the splenic tissue in both
C G, Begley +5 more
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Acta Haematologica, 2009
A 59-year-old man presented with lymphocytosis with huge splenomegaly. The abnormal lymphocytes had a high nucleoplasmxytoplasm ratio, a prominent nucleolus and hairy cytoplasmic projections. Immunophenotyping revealed B-cell leukemia with negative reactions to CD5 and CD25. Cytogenetic study showed 46, XY, der(5)t(5;6)(q35;p21), del(7)(p13)/ 46, idem,
P, Dunn, L Y, Shih, Y S, Ho, H F, Tien
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A 59-year-old man presented with lymphocytosis with huge splenomegaly. The abnormal lymphocytes had a high nucleoplasmxytoplasm ratio, a prominent nucleolus and hairy cytoplasmic projections. Immunophenotyping revealed B-cell leukemia with negative reactions to CD5 and CD25. Cytogenetic study showed 46, XY, der(5)t(5;6)(q35;p21), del(7)(p13)/ 46, idem,
P, Dunn, L Y, Shih, Y S, Ho, H F, Tien
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Cladribine in Hairy Cell Leukemia
Hematology/Oncology Clinics of North America, 2006Cladribine results in prolonged complete remissions in most patients wo have HCL. Several studies have indicated that patients who are in complete remission have survivals that are comparable to those of normal age-matched controls. HCL-related mortality is distinctly uncommon.
Rajesh, Belani, Alan, Saven
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1996
The diagnosis of HCL rests on the identification of HCs; a combination of characteristics — typical nuclear, membrane and cytoplasmic features — should be sought. The membrane hairs are the most obvious feature and are distinguished from those in other conditions by their frequency and fine nature.
John Burthem, John C. Cawley
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The diagnosis of HCL rests on the identification of HCs; a combination of characteristics — typical nuclear, membrane and cytoplasmic features — should be sought. The membrane hairs are the most obvious feature and are distinguished from those in other conditions by their frequency and fine nature.
John Burthem, John C. Cawley
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Toxoplasmosis in hairy‐cell leukaemia
British Journal of Haematology, 1986Summary. Toxoplasma serology was performed in 28 patients with hairy‐cell leukaemia and was positive in eight patients (29%). In two patients (7%) reactivated toxoplasmosis was proven by either isolation of Toxoplasma gondii or by significant antibody titre rise with generation of specific IgM‐antibodies.
H, Knecht, K, Rhyner, R A, Streuli
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