Results 231 to 240 of about 15,589 (303)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

An efficient genetic transformation system mediated by Rhizobium rhizogenes in fruit trees based on the transgenic hairy root to shoot conversion. [PDF]

Plant Biotechnol J
Liu L, Qu J, Wang C, Liu M, Zhang C, Zhang X, Guo C, Wu C, Yang G, Huang J, Yan K, Shu H, Zheng C, Zhang S.   +13 more
europepmc   +1 more source

Humic Acid-Induced Hairy Root Growth in Basil Ismodulated by Nitric Oxide and Reactive Oxygen Species

, 2017
Flávio Couto Cordeiro, Claudete Santa‐Catarina, Vanildo Silveira, Roberta Cristiane Ribeiro, Sônia Regina de Souza   +4 more
openalex   +2 more sources

Reconfigurable Acoustofluidic Microvortices for Selective Microcargo Delivery

Advanced Science, EarlyView.
This work introduces a frequency‐encoded, reconfigurable acoustofluidic system that overcomes the low throughput and poor selectivity of conventional micro‐delivery methods. By exploiting discrete microbubble resonances to program adaptive microvortex modes, the platform enables real‐time switching and selective guidance of microscale payloads through ...
Lei Wang, Yiqiang Wu, Yiyang Tang, Hui Wei, Tianshi Lyu, Xin Zhang, Tian‐Yun Huang   +6 more
wiley   +1 more source

The use of hairy roots and plants regenerated from hairy roots induced by Agrobacterium rhizogenes

Root Research, 1992
openaire   +2 more sources

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Proteomic profiling of peanut hairy root culture unveils distinctive adaptive responses induced by elicitor treatment across diverse time intervals

Chanyanut Pankaew, Phadtraphorn Chayjarung, Chonnikan Tothong, Sompop Pinit, Wannapa Khanthit, Sirinan Temwong, Arpassara Maliprom, Sittiruk Roytrakul, Apinun Limmongkon   +8 more
openalex   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

A Highly Efficient <i>Agrobacterium rhizogenes</i>-Mediated Hairy Root Transformation Method of <i>Idesia polycarpa</i> and the Generation of Transgenic Plants. [PDF]

Plants (Basel)
Wang H, Cheng K, Li T, Lan X, Shen L, Zhao H, Lü S.   +6 more
europepmc   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source