Results 151 to 160 of about 1,593,354 (203)

A 4′‐Thioribouridine Modification Mimics 2′‐O‐Methoxyethyl in ASO‐Like 20‐Mers Targeting PTEN Knockdown

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
A 4′‐thiouridine phosphoramidite was prepared and site‐selectively incorporated into PTEN‐targeting gapmer ASOs. Flank‐modified gapmers with defined phosphorothioate linkage patterns maintained potent target knockdown under transfection and gymnotic delivery, matching 2′‐O‐methoxyethyl comparators and highlighting 4′‐thioribose as a valuable motif for ...
Joanna E. Parkes, Caecilie M. M. Benckendorff, Anna L. Malinowska, Jacob Roberts, Harley L. Huynh, Sritama Bose, Loïc M. Cochard, Aisling Ní Cheallaigh, Sarah L. Lovelock, Peter L. Oliver, Gavin J. Miller   +10 more
wiley   +1 more source

Methylation of DNA duplexes regulates cGAS-mediated innate immune activation <i>via</i> condensate formation. [PDF]

RSC Chem Biol
Morihiro K, Baba M, Yamada M, Okamoto A.
europepmc   +1 more source

Assembly of Protein-DNA Framework Nanostructures: Structurally Defining Protein-DNA Interfaces With Aptamer. [PDF]

Angew Chem Int Ed Engl
Zhang Z, Nan X, Huang Z, Jin J, Tian C, Chen L, Hu X, He H, Yang YR, Huang CZ, Mao C, Zuo H.   +11 more
europepmc   +1 more source

Left-Handed Helices in DNA Nanotechnology. [PDF]

JACS Au
Selvam S, Mathivanan J, Chandrasekaran AR.   +2 more
europepmc   +1 more source

Fully Reversible Regulation of 8‐17 DNAzyme Activity Using Nucleoside‐Based Diarylethenes

Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
The site‐specific incorporation of nucleosidic diarylethenes into the 8–17 deoxyribozyme (DNAzyme) identified position 2.1 as optimal. Compound dU‐PhtBu enabled efficient light‐dependent control of catalytic activity, while maintaining thermal stability and reversibility.
Jörn Bargstedt, Simon M. Büllmann, Sophia Conwell, Andres Jäschke   +3 more
wiley   +1 more source

Cooperative Design of Ranging and Communication for In-Band Full-Duplex Inter-Satellite Links. [PDF]

Sensors (Basel)
Feng H, Yang Z, Ma H, Jiao Y, Wu T, Cai Y, Ma H, Shan Z.   +7 more
europepmc   +1 more source

Fluid Injection Triggers Large‐Scale Slow‐Slip Activation of the Rocky Mountain Fold and Thrust Belt

Geophysical Research Letters, Volume 53, Issue 17, 16 September 2026.
Abstract Using interferometric synthetic aperture radar (InSAR) we show that hydraulic fracturing treatments near the subsurface deformation limit of the Rocky Mountain Fold and Thrust Belt produced 12 intraplate, aseismic, slow‐slip events with magnitudes Mw ${M}_{w}$ 4.71–5.06 at 1,640–2,410 m depths.
Mirko van der Baan, Sergey Samsonov, Hannes Vasyura‐Bathke, Raisha Pradisti, David W. Eaton, Hongxue Han   +5 more
wiley   +1 more source

Small RNA Barcodes for Sensitive Labeling of AAV Transcripts. [PDF]

eNeuro
Magaña Y, Wang S, Torreblanca-Zanca A, Wei L, Castle MJ.   +4 more
europepmc   +1 more source

Investigating Dietary microRNA Stability and Function Using a Transgenic Milk Model With Unique microRNA Sequences

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Upon ingestion, milk extracellular vesicles (EVs) carrying bioactive cargo such as microRNAs may survive digestion and remain bioactive. Here, milk from wild‐type and transgenic cows expressing unique microRNAs was used to isolate and characterize four EV populations.
Zeinab Husseini, Nathalie Majeau, Ismail Fliss, Abderrahim Benmoussa   +3 more
wiley   +1 more source

Structural and Functional Insights Into (S)-5'-C-Guanidinopropyl Uridine-Modified Oligonucleotides With 2'-O-Methyl and 2'-Fluoro Substitutions for RNAi Therapeutics. [PDF]

ChemMedChem
Masaki S, Mahmoud EM, Sakamoto S, Ueno Y.   +3 more
europepmc   +1 more source