Results 1 to 10 of about 1,018,067 (289)

Advancing perovskite photovoltaic technology through machine learning‐driven automation

InfoMat
Since its emergence in 2009, perovskite photovoltaic technology has achieved remarkable progress, with efficiencies soaring from 3.8% to over 26%. Despite these advancements, challenges such as long‐term material and device stability remain.
Jiyun Zhang, Jianchang Wu, Vincent M. Le Corre, Jens A. Hauch, Yicheng Zhao, Christoph J. Brabec   +5 more
doaj   +1 more source

Malignant pleural effusion facilitates the establishment and maintenance of tumor organoid biobank with multiple patient-derived lung tumor cell sources

Experimental Hematology & Oncology
The Patient-Derived Organoids (PDOs) has demonstrated significant potential in personalized medicine. However, the initial establishment of lung cancer organoids (LCOs), and timely therapeutic recommendations face several challenges.
Lingwei Wang, Yanli Yu, Yanhua Fang, Yanjiao Li, Weiting Yu, Zhe Wang, Jinyan Lv, Ruoyu Wang, Shanshan Liang   +8 more
doaj   +1 more source

Nanopore sequencing-derived methylation biomarker prediction for methylation-specific PCR in patients with head and neck squamous cell carcinoma

Clinical Epigenetics
Background DNA methylation of CpG islands is altered in cancer cells. Hypermethylation of single CpG islands in the promoter regions of tumor-suppressor genes occurs already in the early stages of cancer.
Daria Meyer, Anne Hennig, Anna-Bawany Hums, Orlando Guntinas-Lichius, Martina Schmitz, Manja Marz   +5 more
doaj   +1 more source

Spatiotemporal characteristics of environmental microbial communities and resistomes in intensive care units of a tertiary hospital in northwest China

Frontiers in Microbiology
BackgroundIntensive care units (ICUs) are high-risk settings for healthcare-acquired infections (HAIs). It is essential to characterize the microorganisms and antimicrobial resistance genes (ARGs) in ICU environments for prevention and control of HAIs ...
Jiexi Yan, Jiexi Yan, Qingmiao Ren, Qingmiao Ren, Xiaomin He, Haiyun Du, Haiyun Du, Lijuan He, Zhaoyu Zheng, Zhaoyu Zheng, Yaya Qi, Yaya Qi, Xiaohong Xian, Xiaohong Xian   +13 more
doaj   +1 more source

Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors

SLAS Technology
Covalent drug discovery has garnered renewed interest due to its potential to target proteins previously considered ''undruggable.'' Intact protein mass spectrometry (MS) is a critical technique for providing direct evidence of covalent drug ...
Ronghai Cheng, Adil Muneer, Maria Hercher, Bekim Bajrami, Reza Nemati   +4 more
doaj   +1 more source

Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma

SLAS Discovery
High Throughput Screening (HTS) with 3D cell models is possible thanks to the recent progress and development in 3D cell culture technologies. Results from multiple studies have demonstrated different drug responses between 2D and 3D cell culture.
Luis M. Ortiz Jordan, Virneliz Fernández Vega, Justin Shumate, Adam Peles, Jordan Zeiger, Louis Scampavia, Timothy P. Spicer   +6 more
doaj   +1 more source

Comprehensive survey of conserved RNA secondary structures in full-genome alignment of Hepatitis C virus

Scientific Reports
Hepatitis C virus (HCV) is a plus-stranded RNA virus that often chronically infects liver hepatocytes and causes liver cirrhosis and cancer. These viruses replicate their genomes employing error-prone replicases. Thereby, they routinely generate a large ‘
Sandra Triebel, Kevin Lamkiewicz, Nancy Ontiveros, Blake Sweeney, Peter F. Stadler, Anton I. Petrov, Michael Niepmann, Manja Marz   +7 more
doaj   +1 more source

PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1

Nature Communications
Cells need to reprogram their metabolism to adapt to extracellular nutrient changes. The yeast histone acetyltransferase SAGA (Spt-Ada-Gcn5-acetyltransferase) has been reported to acetylate its subunit Ada3 and form homo-dimers to enhance its ability to ...
Wenjing Dai, Qi Yu, Rui Ma, Zhu Zheng, Lingling Hong, Yuqing Qi, Fei He, Min Wang, Feng Ge, Xilan Yu, Shanshan Li   +10 more
doaj   +1 more source

Measuring performance in cancer services during COVID-19 and beyond: a novel case throughput metric using NHS Cancer Waiting Times data. [PDF]

J Public Health (Oxf)
Lam CHM, Mason T, Hollingsworth B.
europepmc   +1 more source

MAXTIA: A high-throughput platform for rapid functional epitope mapping by kinetic screening of mutant libraries. [PDF]

Protein Sci
Kim K, Matsunaga R, Yokoo T, Nakakido M, Tsumoto K.   +4 more
europepmc   +1 more source