Results 61 to 70 of about 1,458,239 (269)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

New Criteria for Sharp Oscillation of Second-Order Neutral Delay Differential Equations

Mathematics, 2021
In this paper, new oscillation criteria for second-order half-linear neutral delay differential equations are established, using a recently developed method of iteratively improved monotonicity properties of a nonoscillatory solution. Our approach allows
Irena Jadlovská
doaj   +1 more source

On kinks and other travelling-wave solutions of a modified sine-Gordon equation

, 2015
We give an exhaustive, non-perturbative classification of exact travelling-wave solutions of a perturbed sine-Gordon equation (on the real line or on the circle) which is used to describe the Josephson effect in the theory of superconductors and other ...
Fiore, Gaetano, Guerriero, Gabriele, Maio, Alfonso, Mazziotti, Enrico   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Hartman-type comparison theorems for half-linear differential equations of the second order

Electronic Journal of Qualitative Theory of Differential Equations, 2012
Comparison theorem of the Hartman type for a continuous family of nonlinear differential equations of the form $$ \big(p(t, \lambda)\varphi(u')\big)' + q(t,\lambda) \varphi(u) = 0, \lambda \geq 0, \quad \tag{ $\rm E_\lambda$}$$ where $ p \in \mathrm{C ...
Jaroslav Jaroš
doaj   +1 more source

Variational properties and orbital stability of standing waves for NLS equation on a star graph

, 2014
We study standing waves for a nonlinear Schr\"odinger equation on a star graph {$\mathcal{G}$} i.e. $N$ half-lines joined at a vertex. At the vertex an interaction occurs described by a boundary condition of delta type with strength $\alpha\leqslant 0 ...
Adami, R., Cacciapuoti, C., Finco, D., Noja, D.   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Forced Oscillation of Second-Order Half-Linear Dynamic Equations on Time Scales

Abstract and Applied Analysis, 2010
We will establish a new interval oscillation criterion for second-order half-linear dynamic equation (r(t)[xΔ(t)]α)Δ+p(t)xα(σ(t))=f(t) on a time scale T which is unbounded, which is a extension of the oscillation result for second order linear dynamic ...
Quanwen Lin, Baoguo Jia, Qiru Wang
doaj   +1 more source

Boundedness and Stability of Impulsively Perturbed Systems in a Banach Space

, 1993
Consider a linear impulsive equation in a Banach space $$\dot{x}(t)+A(t)x(t) = f(t), ~t \geq 0,$$ $$x(\tau_i +0)= B_i x(\tau_i -0) + \alpha_i,$$ with $\lim_{i \rightarrow \infty} \tau_i = \infty $.
A. Bressan, D. D. Bainov, D. D. Bainov, D. D. Bainov, D. D. Bainov, E. Braverman, J. L. Massera, Ju. L. Daleckiî, L. Berezansky, P. P. Zabreiko, V. D. Millman   +10 more
core   +1 more source