Results 81 to 90 of about 1,458,239 (269)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Small solutions of the damped half-linear oscillator with step function coefficients

Electronic Journal of Qualitative Theory of Differential Equations, 2016
In this paper we consider the damped half-linear oscillator \begin{equation*} x''|x'|^{n-1} + c(t) |x'|^{n-1} x' + a(t)|x|^{n-1}x=0, \qquad n \in \mathbb{R}^+. \end{equation*} We give a sufficient condition guaranteeing the existence of a small solution,
Attila Dénes, László Székely
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The boundary value problem for an ordinary linear half-order differential equation

Қарағанды университетінің хабаршысы. Математика сериясы
This study is devoted to the study of the solution of a boundary value problem for an ordinary linear differential equation of half order with constant coefficients.
N. Aliyev, M. Rasulov, B. Sinsoysal
doaj   +1 more source

Oscillation criteria for second-order half-linear differential equations

Mathematical and Computer Modelling, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Oscillation Criteria Enhanced for Advanced Half‐Linear Dynamic Equations

Journal of Mathematics
The purpose of this study is to develop new iterative oscillation criteria for second‐order half‐linear advanced dynamic equations. These findings improve and extend recently established criteria for the same equation by several authors as well as encompass the existing classical criteria for associated ordinary dynamic equations.
Taher S. Hassan, Elmetwally M. Elabbasy, Naveed Iqbal, Akbar Ali, Khudhayr A. Rashedi, Amir Abdel Menaem   +5 more
openaire   +2 more sources

Oscillations of half-linear second order differential equations

Hiroshima Mathematical Journal, 1995
Let \(\varphi:\mathbb{R}\to\mathbb{R}\) be defined by \(\varphi(s)=|s|^{p-2}s\), with \(p>1\) a fixed number. We extend Sturm's comparison theorem of the linear differential equation \[ {\textstyle {\frac{d}{dt}}} [r(t)u'(t)]+ c(t)u(t)=0 \] to the nonlinear differential equation \[ {\textstyle {\frac{d}{dt}}} \{r(t)\varphi(u'(t))\}+ c(t)\varphi(u(t))=0,
Li, Horng Jaan, Yeh, Cheh Chih
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source