Results 51 to 60 of about 5,415,402 (276)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

On asymptotically periodic solutions of linear discrete Volterra equations [PDF]

, 2010
We show that a class of linear nonconvolution discrete Volterra equations has asymptotically periodic solutions. We also examine an example for which the calculations can be done explicitly.
Győri, István, Reynolds, David W.
core   +2 more sources

Non-oscillation of half-linear differential equations with periodic coefficients

Electronic Journal of Qualitative Theory of Differential Equations, 2015
We consider half-linear Euler type differential equations with general periodic coefficients. It is well-known that these equations are conditionally oscillatory, i.e., there exists a border value given by their coefficients which separates oscillatory ...
Petr Hasil, Michal Veselý
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Summation Characterization of the Recessive Solution for Half-Linear Difference Equations

Advances in Difference Equations, 2009
We show that the recessive solution of the second-order half-linear difference equation Δ(rkΦ(Δxk))+ckΦ(xk+1)=0,   Φ(x):=|x|p−2x,  p>1, where r,c are real-valued sequences, is closely related
Simona Fišnarová, Ondřej Došlý   +1 more
doaj   +2 more sources

Generalized discrete Riccati equation and oscillation of half-linear difference equations

Mathematical and Computer Modelling, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Criticality theory of half-linear equations with the (p,A)-Laplacian

, 2014
We study positive solutions of half-linear second-order elliptic equations of the form $$Q_{A,V}(u):= -\mathrm{div} (|\nabla u|_{A}^{p-2}A(x)\nabla u)+ V(x)|u|^{p-2}u=0 \quad \mbox{in }Ω,$$ where ...
Pinchover, Yehuda, Regev, Netanel
openaire   +3 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Euler type linear and half-linear differential equations and their non-oscillation in the critical oscillation case

Journal of Inequalities and Applications, 2019
This paper is devoted to the analysis of the oscillatory behavior of Euler type linear and half-linear differential equations. We focus on the so-called conditional oscillation, where there exists a borderline between oscillatory and non-oscillatory ...
Zuzana Došlá, Petr Hasil, Serena Matucci, Michal Veselý   +3 more
doaj   +1 more source