Results 71 to 80 of about 1,009,185 (275)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Summation Characterization of the Recessive Solution for Half-Linear Difference Equations

Advances in Difference Equations, 2009
We show that the recessive solution of the second-order half-linear difference equation Δ(rkΦ(Δxk))+ckΦ(xk+1)=0,   Φ(x):=|x|p−2x,  p>1, where r,c are real-valued sequences, is closely related
Simona Fišnarová, Ondřej Došlý   +1 more
doaj   +2 more sources

A Fractional Variational Approach for Modelling Dissipative Mechanical Systems: Continuous and Discrete Settings

, 2018
Employing a phase space which includes the (Riemann-Liouville) fractional derivative of curves evolving on real space, we develop a restricted variational principle for Lagrangian systems yielding the so-called restricted fractional Euler-Lagrange ...
Jiménez, Fernando, Ober-Blöbaum, Sina
core   +1 more source

Nonzero electron temperature effects in nonlinear mirror modes [PDF]

, 2009
The nonlinear theory of the magnetic mirror instability (MI) accounting for nonzero electron temperature effects is developed. Based on our previous low-frequency approach to the analysis of this instability and including nonzero electron temperature ...
M. A. Balikhin, Northrop T. G., O. A. Pokhotelov, Ya. N. Istomin   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Euler type linear and half-linear differential equations and their non-oscillation in the critical oscillation case

Journal of Inequalities and Applications, 2019
This paper is devoted to the analysis of the oscillatory behavior of Euler type linear and half-linear differential equations. We focus on the so-called conditional oscillation, where there exists a borderline between oscillatory and non-oscillatory ...
Zuzana Došlá, Petr Hasil, Serena Matucci, Michal Veselý   +3 more
doaj   +1 more source

Half-linear dynamic equations and investigating weighted Hardy and Copson inequalities

Advances in Difference Equations, 2020
In this paper, we employ some algebraic equations due to Hardy and Littlewood to establish some conditions on weights in dynamic inequalities of Hardy and Copson type.
S. H. Saker, A. G. Sayed, Ghada AlNemer, M. Zakarya   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Oscillation and nonoscillation of two terms linear and half-linear equations of higher order

Electronic Journal of Qualitative Theory of Differential Equations, 2010
In this paper we investigate the properties of nonoscillation for the equation $$(-1)^{n}(\rho(t)|y^{(n)}|^{p-2}y^{(n)})^{(n)}-v(t)|y|^{p-2}y=0,$$ where ...
Ryskul. Oinarov, S. Y. Rakhimova
doaj   +1 more source

Generalized discrete Riccati equation and oscillation of half-linear difference equations

Mathematical and Computer Modelling, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources