Results 81 to 90 of about 5,415,402 (276)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source
Oscillation constant for modified Euler type half-linear equations
Electronic Journal of Differential Equations, 2015 Applying the modified half-linear Prufer angle, we study oscillation properties of the half-linear differential equation $$ [ r(t) t^{p-1} \Phi(x')]' + \frac{s(t)}{t \log^pt} \Phi(x) = 0, \quad \Phi(x)=|x|^{p-1}\hbox{sgn} x.
Petr Hasil, Michal Vesely
doaj
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto +12 more
wiley +1 more source
Oscillation and Nonoscillation of Asymptotically Almost Periodic Half-Linear Difference Equations
Abstract and Applied Analysis, 2013 We analyse half-linear difference equations with asymptotically almost periodic coefficients. Using the adapted Riccati transformation, we prove that these equations are conditionally oscillatory.
Michal Veselý, Petr Hasil
doaj +1 more source
Forced oscillation of super-half-linear impulsive differential equations
Computers & Mathematics with Applications, 2007 The aim of this work is to establish new oscillation criteria for forced super-half-linear equations of the form \[ \begin{alignedat}{2} 2 (m(t)\varphi_\alpha(y'))'&+ q(t)\varphi_\beta(y)= f(t),&\quad t&\neq \theta_i,\\ \Delta(m(t)\varphi_\alpha(y'))&+ q_i\varphi_\beta(y)= f_i,&\quad t&= \theta_i,\;i\in\mathbb{N}, \end{alignedat} \] where \(\beta\geq ...
Abdullah Özbekler, Agacik Zafer
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source
MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru +13 more
wiley +1 more source
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source