Results 81 to 90 of about 268,617 (332)

Criticality theory of half-linear equations with the (p,A)-Laplacian

, 2014
We study positive solutions of half-linear second-order elliptic equations of the form $$Q_{A,V}(u):= -\mathrm{div} (|\nabla u|_{A}^{p-2}A(x)\nabla u)+ V(x)|u|^{p-2}u=0 \quad \mbox{in }Ω,$$ where ...
Pinchover, Yehuda, Regev, Netanel
openaire   +3 more sources

On Well-posed Boundary Conditions for the Linear Non-homogeneous Moment Equations in Half-space [PDF]

, 2022
Ruo Li, Yichen Yang
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sturm comparison theorems for some elliptic type equations via Picone-tpye inequalities

Electronic Journal of Qualitative Theory of Differential Equations, 2016
Sturm theorems have appeared as one of the fundamental subjects in qualitative theory to determine properties of the solutions of differential equations. Motivated by some recent developments for half-linear type elliptic equations, we obtain Picone-type
Aydin Tiryaki, Sinem Sahiner, Emine Misirli   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Lyapunov functions for linear nonautonomous dynamical equations on time scales [PDF]

, 2006
The existence of a Lyapunov function is established following a method of Yoshizawa for the uniform exponential asymptotic stability of the zero solution of a nonautonomous linear dynamical equation on a time scale with uniformly bounded ...
Peter E. Kloeden, Kloeden, Peter E., Alexandra Zmorzynska, Zmorzynska, Alexandra   +3 more
core   +1 more source

Hille–Nehari type criteria and conditionally oscillatory half-linear differential equations

Electronic Journal of Qualitative Theory of Differential Equations, 2019
We study perturbations of the generalized conditionally oscillatory half-linear equation of the Riemann–Weber type. We formulate new oscillation and nonoscillation criteria for this equation and find a perturbation such that the perturbed Riemann–Weber ...
Simona Fišnarová, Zuzana Pátíková
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source