Results 81 to 90 of about 1,009,185 (275)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sharp mean-square regularity results for SPDEs with fractional noise and optimal convergence rates for the numerical approximations

, 2016
This article offers sharp spatial and temporal mean-square regularity results for a class of semi-linear parabolic stochastic partial differential equations (SPDEs) driven by infinite dimensional fractional Brownian motion with the Hurst parameter ...
Jiang, Fengze, Qi, Ruisheng, Wang, Xiaojie   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Sturm comparison theorems for some elliptic type equations via Picone-tpye inequalities

Electronic Journal of Qualitative Theory of Differential Equations, 2016
Sturm theorems have appeared as one of the fundamental subjects in qualitative theory to determine properties of the solutions of differential equations. Motivated by some recent developments for half-linear type elliptic equations, we obtain Picone-type
Aydin Tiryaki, Sinem Sahiner, Emine Misirli   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Yang-Mills connections over manifolds with Grassmann structure

, 2003
Let M be a manifold with Grassmann structure, i.e. with an isomorphism of the cotangent bundle T^*M\cong E\otimes H with the tensor product of two vector bundles E and H.
Atiyah, Baulieu, Capria, Chandrashekar Devchand, Corrigan, Corrigan, Devchand, Devchand, Dmitri V. Alekseevsky, Kent, Kostant, Nitta, Nuyts, Nuyts, Singer, Tian, Vicente Cortés, Ward   +17 more
core   +1 more source

Perturbations of Half‐Linear Euler Differential Equation and Transformations of Modified Riccati Equation

Abstract and Applied Analysis, 2012
We investigate transformations of the modified Riccati differential equation and the obtained results we apply in the investigation of oscillatory properties of perturbed half‐linear Euler differential equation. A perturbation is also allowed in the differential term.
Došlý, Ondřej, Funková, Hana
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Linear Differential Equations for a Fractional Spin Field

, 1994
The vector system of linear differential equations for a field with arbitrary fractional spin is proposed using infinite-dimensional half-bounded unitary representations of the $\overline{SL(2,R)}$ group.
Cortes, J. L., Plyushchay, M. S.
core   +2 more sources