Results 41 to 50 of about 9,665,764 (300)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Performance characteristics of mobile MOSFET dosimeter for kilovoltage X-rays used in image guided radiotherapy

Journal of Medical Physics, 2015
The main objective of this study was to investigate the characteristics of metal oxide semiconductor field effect transistor (MOSFET) dosimeter for kilovoltage (kV) X-ray beams in order to perform the in vivo dosimetry during image guidance in ...
A Sathish Kumar, I Rabi Raja Singh, S D Sharma, B Paul Ravindran   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

EVALUATION OF BRACHYTHERAPY FACILITY SHIELDING STATUS IN KOREA OBTAINED FROM RADIATION SAFETY REPORTS

Nuclear Engineering and Technology, 2013
Thirty-eight radiation safety reports for brachytherapy equipment were evaluated to determine the current status of brachytherapy units in Korea and to assess how radiation oncology departments in Korea complete radiation safety reports.
MI HYUN KEUM, SUNG HO PARK, SEUNG DO AHN, WOON-KAP CHO   +3 more
doaj   +1 more source

Enhanced radiation shielding with galena concrete [PDF]

Nuclear Technology and Radiation Protection, 2015
A new concrete, containing galena mineral, with enhanced shielding properties for gamma sources is developed. To achieve optimized shielding properties, ten types of galena concrete containing different mixing ratios and a reference normal ...
Hadad Kamal, Majidi Hosein, Sarshough Samira   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Half-life value evaluation.

, 2021
Sensitivity as a measure of accuracy for the prediction of ectoderm and endomesoderm gene regulatory relations calculated with 5 different median mRNA half-life settings. For the Transcriptomic RNAseq data, 3hrs, 5hrs, 7hrs, 10hrs, 15hrs were tested. For
Doaa Altarawy (5586251), Jingyi Zhang (741111), Sarah L. Tulin (11883691), Emily Najmulski (11883685), Lenwood S. Heath (10287135), Farhan Ibrahim (11883682), George Katholos (11883688)   +6 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Understanding radiation shielding performance through a comparative study of half value layer in novel and preexisting silicate glasses

Nuclear Engineering and Technology
This study focuses on evaluating the PbO-SiO2-B2O3-Na2O glasses' radiation shielding ability against various previously tested materials to gain an in-depth understanding of the glass system's attenuation capabilities.
Albandari.W. Alrowaily, Aljawhara H. Almuqrin, M.I. Sayyed, B. Albarzan   +3 more
doaj   +1 more source

The effect of replacing sand by iron slag on physical, mechanical and radiological properties of cement mortar

HBRC Journal, 2017
In the present study, the effects of replacing sand by high percentages of basic-oxygen furnace slag on the compressive strength, bulk density and gamma ray radiation shielding properties of mortar have been investigated.
Ahmed S. Ouda, Hamdy A. Abdel-Gawwad
doaj   +1 more source