Results 111 to 120 of about 379,037 (236)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Quantum‐Trained AI Enables Inverse Design of Organic Frontier Orbitals at Billion‐Scale

Advanced Science, EarlyView.
Quantum‐trained AI links molecular substructures to frontier‐orbital energetics and enables interpretable screening across nearly one billion GDB‐13 molecules. By combining fragment‐ and ring‐level insights with donor–acceptor energy alignment against ITIC, the framework narrows an immense chemical space to a small set of promising candidates and ...
Yeongnam Ko, Se Jin Kim, Ki Chul Kim
wiley   +1 more source

Lattice Chloride Shielding and Reconstructed Phosphate Armor for Stable Seawater Electrolysis

Advanced Science, EarlyView.
A dual‐protection strategy integrating lattice Cl shielding with dynamically reconstructed phosphate armor enables selective OH adsorption and suppresses chloride‐induced corrosion during alkaline seawater electrolysis, delivering durable operation at industrial‐level current densities.
Yatao Yan, Yuxing Lin, Xing Chen, Shuo Yang, Ke Zhou, Jifang Chen, Lubin Ni, Ming Chen   +7 more
wiley   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Force field models in halogen bonding [PDF]

, 2019
2019 Spring.Includes bibliographical references.Halogen bonding schemes have been proposed to replace those of hydrogen bonding in biomolecules, such as proteins and DNA, because halogens can counter-intuitively attract a Lewis base.
Rappé, Anthony, advisor, Strauss, Stephen, committee member, Prieto, Amy, committee member, Ho, Pui Shing, committee member, Billman, Mardi Marie, author   +4 more
core  

Self‐Healing Ionogel Dual‐Network Enables Synergistic Defect Passivation and Strain Relief for High‐Efficiency Robust Perovskite Photovoltaics

Advanced Science, EarlyView.
PSCs are afflicted by inherent defects and lattice strain that limit PCE and stability. A cross‐linked multifunctional ionogel [HA‐AA][EMIES] is developed to modulate crystallization, relieve residual strain, and passivate defects, extending carrier diffusion length to over 8 µm and delivering PCEs of 26.45% for rigid devices and 25.14% for flexible ...
Wen Wu, Gang Wang, Chen Liu, Xiao‐Li Du, Sheng Yang, Shao‐Long Wang, Jia‐Yi Tian, Ling‐Feng Chao, Xiang‐Feng Deng, Yi Jiang, Yong‐Hua Chen, Gui‐Chuan Xing, Wen‐Yong Lai   +12 more
wiley   +1 more source

Halogen cation transfer in halogen bonding catalysis

The potential of fluorine to participate in halogen bonding (XB) has remained a subject of ongoing debate. The discovery of N-fluoropyridinium triflate as a unique "F-cation organocatalyst" for aziridine synthesis is considered to be the first reported ...
Tan, Hao-Dong, Bew, Sean, Sue, Xiao-Song, Cai, Liu   +3 more
core   +1 more source

Enhancing Quasi‐Two‐Dimensional Electronic Structure in Bi2O2Se via Chlorine Substitution

Advanced Science, EarlyView.
We demonstrate chlorine substitution as an effective strategy to transform Bi2O2Se into an exfoliatable van der Waals superlattice. Key electronic band feature, including indirect bandgap, effective mass is well preserved, while the 2D character of the system is sufficiently enhanced.
Yong‐Zhen Jiang, Qi‐Xun Wen, Xiang Xu, Su‐Tao Sun, Feng‐Fan Ren, Zi‐Xuan Zhou, Xing‐Yuan You, Yu‐Cheng Kan, Zheng Zhang, Jie‐Yi Liu, Yu‐Zhou Zhao, Zheng‐Tai Liu, Mao Ye, Shu‐Hua Yao, Jian Zhou, Yan‐Bin Chen, Zhong‐Kai Liu, Yu‐Lin Chen, Yang‐Yang Lv, Cheng Chen   +19 more
wiley   +1 more source

Multifunctional Ionic Liquid Enabling Cation Homogenization and Lead Chelation for Pure‐Iodide Wide‐Bandgap Perovskite Solar Cells

Advanced Science, EarlyView.
This work presents a multifunctional ionic liquid, [SO3H‐PMIm][OTf], that addresses A‐site cation inhomogeneity and lead toxicity in pure‐iodide wide‐bandgap perovskite solar cells. The additive enables homogeneous cation distribution, achieving 22.02% efficiency with 90% retention after 3000 h and reducing lead leakage by over 58%, thereby ...
Kai Wu, Lei Yang, Guoqing Du, Xin Wang, Jiali Wei, Tiantian Li, Pengfei Zhang, Xiaodan Zhang, Fuhua Hou   +8 more
wiley   +1 more source

Halogen bonding two-point recognition with terphenyl derivatives

, 2018
Neutral terphenyl-based halogen bond donors form two-point halogen bonding motifs with oxadiazoles in the solid state.
C. Ruiz-Pérez, G. Rojas, C. A. Jiménez, J. Pasán, D. Bulfield, P. I. Hidalgo, J. Stoesser, S. M. Huber   +7 more
core   +1 more source