Results 1 to 10 of about 11,572 (118)

Halogen-Containing Drugs in 2025: A Record Year for the Therapeutic Use and Synthesis of FDA-Approved Small Molecules [PDF]

Biomolecules
Halogens, particularly fluorine, chlorine, and bromine, play a pivotal role in modern drug discovery and development. Their incorporation into drug molecules significantly influences physicochemical properties, including lipophilicity, metabolic ...
Davide Benedetto Tiz, Marco D’Alì, Nunzio Iraci, Claudio Santi, Luca Sancineto   +4 more
doaj   +2 more sources

Dynamic and Static Nature of XH-∗-π and YX-∗-π (X = F, Cl, Br, and I; Y = X and F) in the Distorted π-System of Corannulene Elucidated with QTAIM Dual Functional Analysis

Molecules, 2023
The dynamic and static nature of the XH-∗-π and YX-∗-π (X = F, Cl, Br, and I; Y = X and F) interactions in the distorted π-system of corannulene (π(C20H10)) is elucidated with a QTAIM dual functional analysis (QTAIM-DFA), where asterisks emphasize the ...
Satoko Hayashi, Takahiro Kato, Yuji Sugibayashi, Waro Nakanishi   +3 more
doaj   +1 more source

Halogen Enrichment of Siberian Traps Magmas During Interaction With Evaporites

Frontiers in Earth Science, 2021
Volatile emissions to the atmosphere associated with the Siberian Traps eruptions at the Permian-Triassic boundary were sourced from the outgassing of primary magmas and the sedimentary host rocks into which they were intruded. Halogens in volcanic gases
Svetlana Sibik, Marie Edmonds, Benoit Villemant, Henrik H. Svensen, Alexander G. Polozov, Sverre Planke, Sverre Planke   +6 more
doaj   +1 more source

Halogen-Based 17β-HSD1 Inhibitors: Insights from DFT, Docking, and Molecular Dynamics Simulation Studies

Molecules, 2022
The high expression of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) mRNA has been found in breast cancer tissues and endometriosis. The current research focuses on preparing a range of organic molecules as 17β-HSD1 inhibitors.
Arulsamy Kulandaisamy, Murugesan Panneerselvam, Rajadurai Vijay Solomon, Madhavan Jaccob, Jaganathan Ramakrishnan, Kumaradhas Poomani, Muralikannan Maruthamuthu, Nagendran Tharmalingam   +7 more
doaj   +1 more source

Kinetics of the Reactions of Ozone with Halogen Atoms in the Stratosphere

Atmosphere, 2021
It is well established that reaction cycles involving inorganic halogens contribute to the depletion of ozone in the atmosphere. Here, the kinetics of O3 with halogen atoms (Cl, Br, and I) were investigated between 180 and 400 K, expanding the ...
S. Vijayakumar, Duminda S. Ranasinghe, David M. Wilmouth   +2 more
doaj   +1 more source

Co-emission of volcanic sulfur and halogens amplifies volcanic effective radiative forcing [PDF]

Atmospheric Chemistry and Physics, 2021
The evolution of volcanic sulfur and the resulting radiative forcing following explosive volcanic eruptions is well understood. Petrological evidence suggests that significant amounts of halogens may be co-emitted alongside sulfur in some explosive ...
J. Staunton-Sykes, T. J. Aubry, T. J. Aubry, Y. M. Shin, J. Weber, L. R. Marshall, N. Luke Abraham, N. Luke Abraham, A. Archibald, A. Archibald, A. Schmidt, A. Schmidt   +11 more
doaj   +1 more source

New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use

Molecules, 2022
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at least one halogen atom (covalently bound).
Davide Benedetto Tiz, Luana Bagnoli, Ornelio Rosati, Francesca Marini, Luca Sancineto, Claudio Santi   +5 more
doaj   +1 more source

Direct C2–H alkylation of indoles driven by the photochemical activity of halogen-bonded complexes

Beilstein Journal of Organic Chemistry, 2023
A light-driven metal-free protocol for the synthesis of sulfone-containing indoles under mild conditions is reported. Specifically, the process is driven by the photochemical activity of halogen-bonded complexes formed upon complexation of a sacrificial ...
Martina Mamone, Giuseppe Gentile, Jacopo Dosso, Maurizio Prato, Giacomo Filippini   +4 more
doaj   +1 more source

High-spectral-resolution Fabry-Pérot interferometers overcome fundamental limitations of present volcanic gas remote sensing techniques

Frontiers in Earth Science, 2023
Remote sensing (RS) of volcanic gases has become a central tool for studying volcanic activity. For instance, ultraviolet (UV) skylight spectroscopy with grating spectrographs (GS) enables SO2 (and, under favourable conditions, BrO) quantification in ...
Jonas Kuhn, Jonas Kuhn, Nicole Bobrowski, Nicole Bobrowski, Guillaume Boudoire, Guillaume Boudoire, Sergio Calabrese, Sergio Calabrese, Giovanni Giuffrida, Marco Liuzzo, Katcho Karume, Dario Tedesco, Dario Tedesco, Thomas Wagner, Ulrich Platt, Ulrich Platt   +15 more
doaj   +1 more source

Sensitivity of tropospheric ozone to halogen chemistry in the chemistry–climate model LMDZ-INCA vNMHC [PDF]

Geoscientific Model Development, 2023
The atmospheric chemistry of halogenated species (Cl, Br, I) participates in the global chemical sink of tropospheric ozone and perturbs the oxidising capacity of the troposphere, notably by influencing the atmospheric lifetime of methane.
C. Caram, S. Szopa, A. Cozic, S. Bekki, C. A. Cuevas, A. Saiz-Lopez   +5 more
doaj   +1 more source