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Intra‐ and Interethnic Variability in Reduced Haloperidol to Haloperidol Ratios
The Journal of Clinical Pharmacology, 1995Steady‐state haloperidol and reduced haloperidol concentrations were measured in 250 schizophrenic patients from 4 ethnic groups: 39 Blacks, 66 Caucasians, 82 Chinese, and 63 Mexican Americans. The distribution of the reduced haloperidol to haloperidol concentration (RH/HL) ratios was bimodal in all ethnic groups, with the antimode determined by probit
Chester M. Davis +7 more
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Biological Psychiatry, 1989
Twelve male chronic schizophrenic inpatients, neuroleptic-free for at least 4 weeks, were given an oral test dose of 10 mg haloperidol (HAL) and reduced HAL (RHAL) in a random order, with a 2-week interval. Two weeks after the last test dose, the patients were given HAL, 5 mg orally twice daily for 7 days.
Lin Shih-Ku +7 more
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Twelve male chronic schizophrenic inpatients, neuroleptic-free for at least 4 weeks, were given an oral test dose of 10 mg haloperidol (HAL) and reduced HAL (RHAL) in a random order, with a 2-week interval. Two weeks after the last test dose, the patients were given HAL, 5 mg orally twice daily for 7 days.
Lin Shih-Ku +7 more
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Haloperidol for agitation in dementia
Cochrane Database of Systematic Reviews, 2002Agitation occurs in up to 70% of demented patients. Haloperidol has been used for decades to control agitation in dementia, but its effectiveness remains unclear. Previous meta-analyses examined only English language publications or compared haloperidol with other drugs rather than with placebo.
Jay S. Luxenberg +3 more
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Plasma Haloperidol and Reduced Haloperidol Concentrations in a Geriatric Population
Neuropsychobiology, 1996Haloperidol (HL) and reduced haloperidol (RH) plasma concentrations were measured in geriatric patients (n = 45) and schizophrenic patients (n = 8). In the elderly patients, HL doses were 1-4 mg/day while only 2 mg/day was used in the schizophrenics. At HL 2 mg/day dose in both age groups, mean plasma HL levels were approximately twice as high in the ...
Wen-Ho Chang +5 more
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Hope for haloperidol in delirium
The Lancet Respiratory Medicine, 2013Item does not contain ...
Boogaard, M. van den, Pickkers, P.
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Nordisk Psykiatrisk Tidsskrift, 1968
Haloperidol (Haldol, Serenase) och metylperidol (Moperone, Luvatren) ar tva neuroleptika, som hor till butyrofenonserien. Bada ar syntetiserade vid Paul Janssens laboratorier i Beerse i Belgien.
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Haloperidol (Haldol, Serenase) och metylperidol (Moperone, Luvatren) ar tva neuroleptika, som hor till butyrofenonserien. Bada ar syntetiserade vid Paul Janssens laboratorier i Beerse i Belgien.
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Effects of haloperidol and reduced haloperidol on binding to σ sites
European Journal of Pharmacology, 1994The s.c. administration of a single dose of 0.1 mg/kg of reduced haloperidol to guinea pigs produced a marked inhibition of the binding of [3H]dextromethorphan and [3H]3-(3-hydroxyphenyl)-N-(n-propyl)piperidine ([3H](+)-3-PPP) to brain. The inhibition was still evident 10 days later, and it was accompanied by residual brain levels of reduced ...
Thomas B. Cooper +2 more
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Psychiatry Research, 1995
Twenty schizophrenic patients were treated with a fixed haloperidol (HL) dose of 20 mg/day for 4 weeks. The conversion of HL to its reduced metabolite (reduced haloperidol, RH) occurs via the ketone reductase enzyme. RH is also converted back to HL by the cytochrome P450 2D6 isozyme. Ketone reductase activity can be measured in red blood cells.
Ming Cheng Chung +5 more
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Twenty schizophrenic patients were treated with a fixed haloperidol (HL) dose of 20 mg/day for 4 weeks. The conversion of HL to its reduced metabolite (reduced haloperidol, RH) occurs via the ketone reductase enzyme. RH is also converted back to HL by the cytochrome P450 2D6 isozyme. Ketone reductase activity can be measured in red blood cells.
Ming Cheng Chung +5 more
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Pharmacodynamics and pharmacokinetics of haloperidol and reduced haloperidol in guinea pigs
Psychopharmacology, 1988Striatal homovanillic acid (HVA) levels and drug concentrations in striatum and plasma were examined in guinea pigs after acute and subchronic administrations of haloperidol (HAL) and reduced HAL (RHAL). HVA and drug levels were measured by high performance liquid chromatography with electrochemical detection. HAL and RHAL were interconverted in 10 min.
Wen-Ho Chang +4 more
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Dosage of Haloperidol for Mania
British Journal of Psychiatry, 1994BackgroundWe compared three doses of a neuroleptic as a treatment for mania.MethodForty-seven newly admitted in-patients with mania were randomised to receive 10, 30, or 80 mg a day of oral haloperidol, under double-blind conditions for up to six weeks.
Michael Borenstein +4 more
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