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Pharmacodynamics and pharmacokinetics of haloperidol and reduced haloperidol in guinea pigs

Psychopharmacology, 1988
Striatal homovanillic acid (HVA) levels and drug concentrations in striatum and plasma were examined in guinea pigs after acute and subchronic administrations of haloperidol (HAL) and reduced HAL (RHAL). HVA and drug levels were measured by high performance liquid chromatography with electrochemical detection. HAL and RHAL were interconverted in 10 min.
Wen-Ho Chang +4 more
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The plasma haloperidol and reduced haloperidol concentrations in chinese schizophrenic patients: Relationship between reduced haloperidol/haloperidol ratio and red blood cell haloperidol reductase activity

Human Psychopharmacology: Clinical and Experimental, 1992
AbstractFifteen chinese schizophrenic patients were given titrated doses of haloperidol (0.05‐0.42 mg/kg) for two weeks. All these 15 patients were in clinical remission on maintenance dose of haloperidol. The mean plasma haloperidol and reduced haloperidol concentrations were 16.8 ± 4.8 ng/ml and 13.6‐ 5.7 ng/ml respectively. The plasma RHAL/HAL ratio
M. T. H. Wong +3 more
openaire +2 more sources

HALOPERIDOL