Results 51 to 60 of about 454,931 (246)
Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7
Advanced Science, EarlyView.Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim +16 more
wiley +1 more source
TUHH Technische Universität Hamburg 2022, Jahresbericht
Das Jahr 2022 war ein Jahr zwischen Hoffnung und Unsicherheit, durch das wir als Technische Universität Hamburg gemeinsam sehr gut gekommen sind. Für den Optimismus und die tatkräftige Unterstützung danke ich allen Mitgliedern und Angehörigen der TU ...
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Quellen zur jüdischen Familiengeschichtsforschung im Staatsarchiv Hamburg.Ein Wegweiser für die Spurensuche [PDF]
, 2015 Das Archivgut zur Geschichte der in der NS-Zeit venichteten jüdischen Gemeinden Hamburgs ist in großem Umfang erhalten geblieben. Es ermöglicht vertiefte familiengeschichtliche und biografische Nachforschungen in zahlreichen Beständen des Staatsarchivs ...
Sielemann, Jürgen
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Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Shared molecular pathways in pediatric genetic epilepsies: Insights from a single-center cohort of 80 patients. [PDF]
Epilepsia OpenAbstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Hecher L +11 more
europepmc +2 more sources
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Advanced Science, EarlyView.Ti substitution stabilizes Co‐free high‐Ni layered oxides through both structural and electronic effects. TiO6 octahedra act as compensatory structural units that help interrupt cooperative Jahn–Teller distortion and suppress detrimental phase transitions, while the electron‐withdrawing inductive effect of Ti stabilizes the oxygen lattice. As a result,
Bixian Ying +19 more
wiley +1 more source
Technische Universität Hamburg-Harburg 1999, Jahresbericht
, 2006 Jahresbericht des Präsidenten der TU Hamburg-Harburg für das Jahr ...
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