Results 101 to 110 of about 2,154 (279)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Small size and rotary inertia effects on the natural frequencies of carbon nanotubes

Curved and Layered Structures, 2018
In the present paper, rotary inertia and small size effects on the free vibration response of single-walled carbon nanotubes are examined. The equations in motion and associated boundary conditions are obtained by using Hamilton’s principle on the basis ...
Civalek Ömer, Ersoy Hakan, Numanoğlu Hayri Metin, Akgöz Bekir   +3 more
doaj   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

The Importance of Metal‐Organic Framework Linker Atoms for CO2 Reduction: A DFT Study

Advanced Science, EarlyView.
Using DFT, we examine the role of linker atoms in CO2 reduction on copper‐based metal organic frameworks (Cu MOFs). Our calculations reveal that linker atoms may serve as both CO2 and H‐shuttling sites and suggest linker electrostatics as a descriptor for linker activity. ABSTRACT Although the metal within the secondary building unit of a metal‐organic
Ugochukwu Nwosu, Samira Siahrostami
wiley   +1 more source

Dynamic Analysis of a Tapered Composite Thin-Walled Rotating Shaft Embedded with SMA Wires Using the Generalized Differential Quadrature Method

Shock and Vibration, 2020
A dynamical model is developed for the tapered composite thin-walled rotating shaft with shape memory alloy (SMA) wires embedded in. The SMA wires are embedded at an interlayer of the shaft and arranged along the conical surface of the tapered composite ...
Weiyan Zhong, Feng Gao, Yongsheng Ren, Xiaoxiao Wu, Hongcan Ma   +4 more
doaj   +1 more source

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

Variational energy principle for compressible, baroclinic flow. 2: Free-energy form of Hamilton's principle

, 1977
The first and second variations are calculated for the irreducible form of Hamilton's Principle that involves the minimum number of dependent variables necessary to describe the kinetmatics and thermodynamics of inviscid, compressible, baroclinic flow in
Schmid, L. A.
core  

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

An Accurate Solution Method for the Static and Vibration Analysis of Functionally Graded Reissner-Mindlin Rectangular Plate with General Boundary Conditions

Shock and Vibration, 2018
This paper presents an accurate solution method for the static and vibration analysis of functionally graded Reissner-Mindlin plate with general boundary conditions on the basis of the improved Fourier series method.
Haichao Li, Ning Liu, Fuzhen Pang, Yuan Du, Shuo Li   +4 more
doaj   +1 more source

Dynamic higher order equations

, 2016
The subject of this thesis is to derive and evaluate governing equations and corresponding boundary conditions for solid cylinders and rectangular plates, where the material constituting the cylinder or plate are governed by classical elasticity ...
Abadikhah, Hossein
core