Results 71 to 80 of about 1,071 (239)

Quantization of the Hamilton equations of motion

Physica Scripta
Abstract One of the fundamental problems in quantum mechanics is finding the correct quantum image of a classical observable that would correspond to experimental measurements. We investigate for the appropriate quantization rule that would yield a Hamiltonian that obeys the quantum analogue of Hamilton’s equations of motion, which ...
Ramon Jose C Bagunu, Eric A Galapon
openaire   +2 more sources

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Free flexural vibrations of standard wide-flange H-beams with consideration of the shear effect

Pojazdy Szynowe
The subject of the paper is a simply supported standard wide-flange H-beam. Cross sections of this beam is analytically described as a three-layer structure.
Krzysztof Magnucki
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

The Orbital Evolution of 2 Binary Asteroid Systems Based on Hamel’s Variational Integrators

Space: Science & Technology
In the full n-body problem, the mutual gravitational potential energy of the rigid body is determined by its position and attitude, which leads to the coupling of the translational and rotational motions.
Ben Niu, Ziheng Huang, Zizheng Gong, Shixing Liu, Yongxin Guo   +4 more
doaj   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Buckling and free flexural vibration of an asymmetric sandwich beam with a functionally graded core

Archives of Mechanics
This paper is devoted to an asymmetrical sandwich beam with a functionally graded core with three different variants of boundary conditions. An analytical model of this beam, considering individual nonlinear shear deformation theory, is developed.
K. Magnucki, E.M. Magnucka-Blandzi, K. Sowiński   +2 more
doaj   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Small size and rotary inertia effects on the natural frequencies of carbon nanotubes

Curved and Layered Structures, 2018
In the present paper, rotary inertia and small size effects on the free vibration response of single-walled carbon nanotubes are examined. The equations in motion and associated boundary conditions are obtained by using Hamilton’s principle on the basis ...
Civalek Ömer, Ersoy Hakan, Numanoğlu Hayri Metin, Akgöz Bekir   +3 more
doaj   +1 more source

Physics‐Informed Neural Network‐Enabled Forward Prediction and Inverse Design of Ring Origami

Advanced Science, EarlyView.
This work presents a KRT‐PINN framework that integrates Kirchhoff rod theory with physics‐informed neural networks for the forward prediction and inverse design of ring origami consisting of closed‐loop rods. The framework predicts stable states of segmented rings with prescribed natural‐curvature profiles and determines the natural‐curvature profiles ...
Luyuan Ning, Lu Lu, Sophie Leanza, Ruike Renee Zhao   +3 more
wiley   +1 more source