Results 101 to 110 of about 446,387 (282)

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Hamilton cycles in sparse robustly expanding digraphs [PDF]

, 2018
The notion of robust expansion has played a central role in the solution of several conjectures involving the packing of Hamilton cycles in graphs and directed graphs.
Lo, Allan, Patel, Viresh
core   +2 more sources

Enumerating all Hamilton Cycles and Bounding the Number of Hamilton Cycles in 3-Regular Graphs [PDF]

The Electronic Journal of Combinatorics, 2011
We describe an algorithm which enumerates all Hamilton cycles of a given 3-regular $n$-vertex graph in time $O(1.276^{n})$, improving on Eppstein's previous bound. The resulting new upper bound of $O(1.276^{n})$ for the maximum number of Hamilton cycles in 3-regular $n$-vertex graphs gets close to the best known lower bound of $\Omega(1.259^{n})$.
openaire   +2 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

k-Ordered Hamilton cycles in digraphs

Journal of Combinatorial Theory, Series B, 2008
Given a digraph D, the minimum semi-degree of D is the minimum of its minimum indegree and its minimum outdegree. D is k-ordered Hamiltonian if for every ordered sequence of k distinct vertices there is a directed Hamilton cycle which encounters these vertices in this order.
Daniela Kühn, Deryk Osthus, Andrew Young   +2 more
openaire   +2 more sources

The Importance of Metal‐Organic Framework Linker Atoms for CO2 Reduction: A DFT Study

Advanced Science, EarlyView.
Using DFT, we examine the role of linker atoms in CO2 reduction on copper‐based metal organic frameworks (Cu MOFs). Our calculations reveal that linker atoms may serve as both CO2 and H‐shuttling sites and suggest linker electrostatics as a descriptor for linker activity. ABSTRACT Although the metal within the secondary building unit of a metal‐organic
Ugochukwu Nwosu, Samira Siahrostami
wiley   +1 more source

Graph Invariants and Large Cycles: A Survey

International Journal of Mathematics and Mathematical Sciences, 2011
Graph invariants provide a powerful analytical tool for investigation of abstract substructures of graphs. This paper is devoted to large cycle substructures, namely, Hamilton, longest and dominating cycles and some generalized cycles including Hamilton ...
Zh. G. Nikoghosyan
doaj   +1 more source

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

Hamilton cycles in graphs and hypergraphs: an extremal perspective [PDF]

, 2014
As one of the most fundamental and well-known NP-complete problems, the Hamilton cycle problem has been the subject of intensive research. Recent developments in the area have highlighted the crucial role played by the notions of expansion and quasi ...
Kühn, Daniela, Osthus, Deryk
core   +1 more source