Results 221 to 230 of about 442,994 (288)

Environmental and temporal factors affecting record white‐tailed deer antler characteristics in Ontario, Canada

open access: yesThe Journal of Wildlife Management, EarlyView.
Antler characteristics are influenced by a combination of genetics, age, and environmental factors, notably habitat quality and resource availability. In this study, we explored how diverse environmental factors, including climate and land cover composition, affect antler size, tine configuration, and the distribution of record‐scoring white‐tailed ...
Brooklyn S. Cars   +5 more
wiley   +1 more source

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

ER degradation for ER<sup>+</sup>/HER2- advanced or metastatic breast cancer: a phase 1 trial. [PDF]

open access: yesNat Commun
Hamilton E   +8 more
europepmc   +1 more source

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen   +7 more
wiley   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

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