Results 191 to 200 of about 74,857 (256)

3,4‐Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50‐kHz ultrasonic vocalisations in tryptophan hydroxylase 2 (Tph2)‐deficient rats lacking serotonin in the central nervous system

British Journal of Pharmacology, EarlyView.
Background and Purpose 3,4‐Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a psychostimulant with entactogenic properties and known to induce arousal and euphoria. As an amphetamine derivate, MDMA acts on the monoamine systems in the brain and stimulates release of dopamine (DA), noradrenaline (NA) and serotonin (5‐HT), yet their ...
Tianhua Wang, Rainer K. W. Schwarting, Markus Wöhr   +2 more
wiley   +1 more source

How Do Female Pest Tephritids Behave During Male Courtship?

Entomologia Experimentalis et Applicata, EarlyView.
In this paper, the female role during male courtship was described for the first time in fruit flies. Our findings show that females imitate some male behaviors and suggest that certain behaviors are associated with male mating success. Indeed, the Mediterranean fruit fly displays fewer behavioral units (i.e., shorter courtship sequences) than ...
Bianca M. Almeida, Alzira Kelly Roriz, Alexandre S. Araújo, Luis Paulo S. Sacramento, Iara S. Joachim‐Bravo   +4 more
wiley   +1 more source

Swiftly identifying strongly unique k-mers. [PDF]

Algorithms Mol Biol
Zentgraf J, Rahmann S.
europepmc   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

A Route to Design Novel Functional Peptides by Applying a Denoising Diffusional Model to mRNA Display Libraries. [PDF]

Chembiochem
Qi P, Gandhi YP, Zheng K, Jalali-Yazdi F, Ong JN, Takahashi TT, Kalia RK, Roberts RW.   +7 more
europepmc   +1 more source

Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery

Epilepsia, EarlyView.
Abstract Objective Precise localization of epileptogenic tissue is critical for successful surgery in drug‐resistant temporal lobe epilepsy (TLE) but is challenging in those requiring intracranial electroencephalography (iEEG). A range of modalities are used for localization, including magnetic resonance imaging (MRI) and EEG, which are typically ...
Csaba Kozma, Jonathan Horsley, Gerard Hall, Callum Simpson, Jane de Tisi, Anna Miserocchi, Beate Diehl, Andrew W. McEvoy, Sjoerd B. Vos, Gavin P. Winston, Yujiang Wang, John S. Duncan, Peter N. Taylor   +12 more
wiley   +1 more source

Sudden restructuring of memory representations in recurrent neural networks with repeated stimulus presentations. [PDF]

Front Comput Neurosci
Howlett JR.
europepmc   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Applications of newly defined diamond Pythagorean fuzzy CODAS method via multi-criteria decision-making problems. [PDF]

PLoS One
Khan MB, Cortez MV, Bin-Mohsin B, Ciurdariu L, Zamri N.   +4 more
europepmc   +1 more source

Evidence for increased background neural noise in migraine with aura: Hyperactive but not hyperresponsive

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study had two aims: (1) to investigate the contrast gain in migraine and compare it to that in photosensitive epilepsy; (2) to explore any effects of colored spectacles (precision ophthalmic tints [POT]) on contrast gain. Background Individuals with migraine with aura (MA) typically show high amplitude electrophysiological ...
Louise O'Hare, Paul B. Hibbard, Arnold J. Wilkins   +2 more
wiley   +1 more source