Results 71 to 80 of about 2,040,890 (241)

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

open access: yesAdvanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li   +7 more
wiley   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

open access: yesAdvanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo   +11 more
wiley   +1 more source

01Hamming28March1995.preliminaries

open access: yes, 1995
"The Art of Doing Science and Engineering: Learning to Learn" was the capstone course by Dr. Richard W. Hamming (1915-1998) for graduate students at the Naval Postgraduate School (NPS) in Monterey California.
Hamming, Richard W.
core   +2 more sources

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

open access: yesAdvanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang   +5 more
wiley   +1 more source

01Hamming28March1995.Orientation

open access: yes, 1995
"The Art of Doing Science and Engineering: Learning to Learn" was the capstone course by Dr. Richard W. Hamming (1915-1998) for graduate students at the Naval Postgraduate School (NPS) in Monterey California.
Hamming, Richard W.
core   +2 more sources

Ultralow‐Energy Analog Reservoir Computing via Reconfigurable 2‐Transistor Memory

open access: yesAdvanced Science, EarlyView.
This work presents a reconfigurable reservoir‐computing platform based on an oxide InSnZnO two‐transistor cell in which a hold bias selects volatile relaxation for the reservoir or quasi‐non‐volatile multilevel storage for the readout. Multi‐level hold‐bias kernel tune relaxation currents to generate diverse time constants, enriching reservoir states ...
Jeong‐Min Park   +11 more
wiley   +1 more source

Tightening Leakage Resilience of the Suffix Keyed Sponge

open access: yesIACR Transactions on Symmetric Cryptology
Lightweight cryptographic constructions are often optimized on multiple aspects that put the security bounds to the limit. In this respect, it is important to obtain security bounds that are tight and give an accurate and exact indication of the generic
Henk Berendsen, Bart Mennink
doaj   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen   +10 more
wiley   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

open access: yesAdvanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang   +15 more
wiley   +1 more source

Research of Hamming weight-based algebraic side-channel attack on LED

open access: yesTongxin xuebao, 2013
:The security of LED against the algebraic side-channel attack (ASCA)was evaluated, which is a lightweight block cipher proposed in CHES 2011.Firstly, the attack model of ASCA was analyzed, and then the design and algebraic representations of LED were ...
Ke-ke JI   +4 more
doaj   +2 more sources

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