Results 11 to 20 of about 259,291 (341)

Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia

Frontiers in Integrative Neuroscience, 2022
We tested the hypothesis that a temporary period of circadian arrhythmia would transiently impair recall of an aversive memory in Siberian hamsters (Phodopus sungorus).
Athreya Steiger, Julia Farfan, Nathan Fisher, H. Craig Heller, Fabian-Xosé Fernandez, Norman F. Ruby   +5 more
doaj   +1 more source

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

Signal Transduction and Targeted Therapy, 2021
Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiological results, we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2 ...
Lunzhi Yuan, Huachen Zhu, Ming Zhou, Jian Ma, Rirong Chen, Yao Chen, Liqiang Chen, Kun Wu, M. Cai, Junping Hong, Li-feng Li, Che Liu, Huan Yu, Yali Zhang, Jia Wang, Tianying Zhang, S. Ge, Jun Zhang, Q. Yuan, Yixin Chen, Qiyi Tang, Honglin Chen, T. Cheng, Y. Guan, N. Xia   +24 more
semanticscholar   +1 more source

Histopathologic Characterization of Experimental Peracute SARS-CoV-2 Infection in the Syrian Hamster

Veterinary Sciences, 2023
Coronavirus Infectious Disease 2019 (COVID-19) initiated a global pandemic that thus far has resulted in the death of over 6.5 million people internationally.
Chad S. Clancy, Kimberly Meade-White, Carl Shaia, Greg Saturday, Heinz Feldmann, Kyle Rosenke   +5 more
doaj   +1 more source

Suppression of Circadian Timing and Its Impact on the Hippocampus

Frontiers in Neuroscience, 2021
In this article, I describe the development of the disruptive phase shift (DPS) protocol and its utility for studying how circadian dysfunction impacts memory processing in the hippocampus.
Norman F. Ruby
doaj   +1 more source

Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models

Frontiers in Microbiology, 2020
We explored an emerging technology to produce anti-Hantaan virus (HTNV) and anti-Puumala virus (PUUV) neutralizing antibodies for use as pre- or post-exposure prophylactics.
Casey C. Perley, Rebecca L. Brocato, Hua Wu, Christoph Bausch, Priya P. Karmali, Jerel B. Vega, Melanie V. Cohen, Brandon Somerville, Steven A. Kwilas, Lucia M. Principe, Joshua Shamblin, Padmanabh Chivukula, Eddie Sullivan, Jay W. Hooper   +13 more
doaj   +1 more source

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

Clinical Infectious Diseases, 2020
Background A physiological small animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between angiotensin-converting enzyme 2 (ACE2) of common laboratory mammals and the receptor-binding domain of ...
J. Chan, A. J. Zhang, Shuofeng Yuan, V. Poon, C. Chan, A. Lee, W. Chan, Zhimeng Fan, H. Tsoi, Lei Wen, Ronghui Liang, Jianli Cao, Yanxia Chen, Kaiming Tang, Cuiting Luo, Jian-Piao Cai, K. Kok, Hin Chu, Kwok-Hung Chan, S. Sridhar, Zhiwei Chen, Honglin Chen, K. To, K. Yuen   +23 more
semanticscholar   +1 more source

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

eLife, 2022
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants of concern (VoCs) and evidence that existing vaccines that were designed to ...
David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse H Erasmus   +14 more
doaj   +1 more source

The role of photoperiod and melatonin in the control of seasonal reproduction in mammals [PDF]

Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego, 2020
Melatonin secreted by pineal cells is a hormone whose biosynthesis is coordinated by neurons of the master clock located in the hypothalamic suprachiasmatic nuclei (SCN), characterized by the generation of a 24-hour rhythm.
Izabela Szpręgiel, Danuta Wronska
doaj   +1 more source

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

Nature Communications, 2020
Despite no or limited pre-clinical evidence, repurposed drugs are massively evaluated in clinical trials to palliate the lack of antiviral molecules against SARS-CoV-2.
Jean-Sélim Driouich, M. Cochin, G. Lingas, G. Moureau, F. Touret, P. Petit, G. Piorkowski, Karine Barthelemy, C. Laprie, B. Coutard, J. Guedj, X. D. de Lamballerie, C. Solas, A. Nougairède   +13 more
semanticscholar   +1 more source

Dynamic Changes of the Blood Chemistry in Syrian Hamsters Post-Acute COVID-19

Microbiology Spectrum, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus disease 2019 (COVID-19). However, the long-term health consequences of COVID-19 are not fully understood. We aimed to determine the long-term lung
Chi-Ju Hsu, Wen-Chin Lin, Yu-Ching Chou, Chuen-Mi Yang, Hsueh-Ling Wu, Yun-Hsiang Cheng, Ping-Cheng Liu, Jia-Yu Chang, Hsing-Yu Chen, Jun-Ren Sun   +9 more
doaj   +1 more source