Results 261 to 270 of about 259,291 (341)

Immunological balance skewing Th1,Th17 towards Th2,Treg in OSCC of hamster induced by 7,12- dimethylbenz[a]anthracene. [PDF]

BMC Oral Health
Shao Q, Li H, Tian Y.
europepmc   +1 more source

Pioneer Factor FOXA1 Boosts CHO Cell Productivity

Biotechnology Journal, Volume 21, Issue 1, January 2026.
Graphical Abstract and Lay Summary FOXA1 binds directly to the EF1α and CMV promoters that are widely used to drive transgene expression. It stimulates transcription by recruiting cofactors that manipulate the epigenetic environment, including TET1 that demethylates DNA, p300 that acetylates histones and SWI/SNF that remodels nucleosomes.
Sienna P. Butterfield, Fay L. Saunders, Robert J. White   +2 more
wiley   +1 more source

Declines in Oxytocin Receptor Density and Social Behavior Across a Dispersal-Like Transition in Solitary Hamsters. [PDF]

Dev Neurobiol
Beery AK, Lee NS, Cooke EM.
europepmc   +1 more source

Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 196-211, January 2026.
In this study, the authors identified regions with enhancer activity in the CHO cell genome using genome‐wide and targeted STARR‐seq. The analysis revealed thousands of newly identified enhancer sequences, where some of the most active sequences could drive transgene expression at levels similar to or higher than strong viral enhancers.
María Santos, Yusuf B. Johari, Laura Biggins, Natalie C. Elliott, Stefan Schoenfelder, Mounika Boddireddy, Daniel K. Fabian, Michael Anbar, Peter M. O'Callaghan, Peter J. Rugg‐Gunn   +9 more
wiley   +1 more source

Virological characterization of SARS-CoV-2 BA.2.86 variants by assessing antiviral susceptibility, in vivo infectivity and replicative fitness. [PDF]

Sci Rep
Giraud E, Piorkowski G, Driouich JS, Bernadin O, Durand C, Gilles M, Amaral R, van der Werf S, de Lamballerie X, Agou F, Nougairède A, Touret F.   +11 more
europepmc   +1 more source

Purification of hamster melanoma tyrosinases and structural studies of their asparagine-linked sugar chains [PDF]

, 1984
隆司 大倉
openalex  

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Cytotoxicity and genotoxicity of glyphosate and Roundup Quickpro on Chinese hamster ovary cells. [PDF]

Sci Rep
Ferdous T, He Q, Zhang W.
europepmc   +1 more source

Application of Dual Virus Spike Approach to Accelerate Early‐Stage Viral Clearance Studies

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 186-195, January 2026.
ABSTRACT Biotechnology products derived from cell lines carry a risk of viral infection. Given this potential risk, an assessment of the virus removal/inactivation that can be achieved by a product's established purification process is required per ICH Q5A guidelines. This viral safety assessment is a critical component of filing an investigational new
Heather Bethea Horne, Thomas B. Lindsey, Leslie S. Wolfe, Symya Chumbris, Matthew Dickson, Akunna Iheanacho   +5 more
wiley   +1 more source

Minimally invasive detection of early-stage opisthorchiasis-associated cholangiocarcinoma using label-free surface-enhanced Raman spectroscopy (SERS) of hamster serum. [PDF]

PLoS One
Chaidee A, Kongsintaweesuk S, Pongking T, Tunbenjasiri K, Mon AM, Pairojkul C, Tanasuka P, Plengsuriyakarn T, Na-Bangchang K, Charoenram N, Blair D, Pinlaor S.   +11 more
europepmc   +1 more source