Results 261 to 270 of about 306,860 (343)

Antiviral and immunomodulatory effect of zapnometinib in animal models and hospitalized COVID-19 patients. [PDF]

Front Immunol
Füll Y, Schüssele LM, Hamza H, Hoffmann H, Bauer M, Stenglein S, Pötz O, Steinhilber A, Anselm V, Delany MW, Van den Brand JMA, Van Amerongen G, De Waal L, Pleschka S, Ludwig S, Planz O.   +15 more
europepmc   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

An Enhanced Metabolization Protocol for In Vitro Genotoxicity Assessment of N-Nitrosamines in Mammalian Cells. [PDF]

Environ Mol Mutagen
Geijer ME, Gernaat AM, Moelijker N, Brandsma I, Hendriks G.   +4 more
europepmc   +1 more source

Surface morphology and distribution of oropharyngeal taste papillae in sharks and rays (Elasmobranchii, Chondrichthyes): Implications for gustatory sensitivity

Journal of Anatomy, Volume 247, Issue 5, Page 924-952, November 2025.
This study investigates the morphology, abundance, and distribution of taste papillae in the oropharyngeal cavity of a range of elasmobranchs using SEM, histology, and topographic analyses. The interspecific importance of gustation is reflected in quantitative differences in the size, density, and distribution of taste papillae, which have implications
Carla J. L. Atkinson, Shaun P. Collin
wiley   +1 more source

Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases. [PDF]

BMC Genomics
Wang C, Cheng Z, Miao J, Xue X, Dong Y, Zhao L, Guo H, Wang J, Wang Z, Lu S, Fang G, Peng Y, Zhai Y, Zhang Z, Gao D, Wang Z, Wang P, Zhang L, Dunmall LSC, Wang J, Tang W, Li X, Ding Z, Zhao X, Li L, Lemoine NR, Wang Z, Tonge D, Tan W, Dong J, Wang Y.   +30 more
europepmc   +1 more source

A New Synthetic Analogue of Protectin DX With Enhanced Therapeutic Potential Against Metabolic‐Associated Steatotic Liver Disease

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The pro‐resolving lipid mediator PDX, and a novel synthetic analogue AN‐48, were orally administered (50 ng/g) daily to hamsters fed an obesity‐inducing diet. AN‐48 prevented hepatic triglyceride accretion and reduced the expression of fatty acid synthase (FASN), responsible for de novo lipogenesis.
Frédérik Desmarais, René Maltais, Jean‐Yves Sancéau, Bruno Marcotte, Geneviève Guèvremont, Jocelyn Trottier, Patricia L. Mitchell, Olivier Barbier, Donald Poirier, André Marette   +9 more
wiley   +1 more source

SARS-CoV-2 variants retain high airborne transmissibility by different strategies. [PDF]

Npj Viruses
Zhou J, Sukhova K, Frise R, Baillon L, Brown JC, Peacock TP, Furnon W, Cowton VM, Patel AH, Palmarini M, Barclay WS.   +10 more
europepmc   +1 more source

Polyribosomes of Hamster Cells

, 1968
Clifford P. Stanners
openalex   +1 more source

Proton First: Rationalizing a Proton Transfer in a Protein‐Fragment Complex

ChemMedChem, Volume 20, Issue 20, October 15, 2025.
We combine experimental and theoretical approaches to investigate benzoic acid binding to Protein Kinase A. The crystal structure shows benzoic acid protonated in the complex. Isothermal titration calorimetry (ITC) fails to detect binding, likely due to low affinity.
Helge Vatheuer, Jonas Paulus, Lisa Johannknecht, Gerald Keller, Rebecca Maria Ziora, Lukas S. Stelzl, Paul Czodrowski   +6 more
wiley   +1 more source