Results 61 to 70 of about 116,204 (266)

Preclinical Models of Oropouche Virus Infection and Disease

Pathogens
Oropouche virus (OROV) is an emerging and underreported arbovirus with dengue-like symptoms confounding diagnosis. OROV is also neuroinvasive, with a small number of cases presenting severe neurological symptoms.
Daniel Morley, Emma Kennedy, Stuart Dowall   +2 more
doaj   +1 more source

A Method for Electrophysiological Characterization of Hamster Retinal Ganglion Cells Using a High-Density CMOS Microelectrode Array

Frontiers in Neuroscience, 2015
Knowledge of neuronal cell types in the mammalian retina is important for the understanding of human retinal disease and the advancement of sight-restoring technology, such as retinal prosthetic devices.
Ian L Jones, Thomas L Russell, Karl eFarrow, Michele eFiscella, Felix eFranke, Jan eMüller, David eJäckel, Andreas eHierlemann   +7 more
doaj   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

Advanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser, Haseeb Muhammad, Junaid Younas, Gillian Lovell, Bianca Migliori, Andreas Dengel, Sheraz Ahmed   +6 more
wiley   +1 more source

Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia

American Journal of Hematology, EarlyView.
ABSTRACT Chronic liver disease (CLD)‐related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD‐related thrombocytopenia who were undergoing elective invasive ...
Yifan Han, Ning Lin, Jinghang Xu, Sikui Wang, Jinglan Jin, Jia Shang, Yongning Xin, Youwen Tan, Dazhi Zhang, Jinlin Hou, Ping An, Wen Xie, Yujuan Guan, Qingfang Xiong, Hong Wu, Huiguo Ding, Yu Chen, Rongkuan Li, Zhili Wen, Mingqin Lu, Jinhui Yang, Zhongyin Zhou, Yongjian Zhou, Zujiang Yu, Kecan Lin, Wei Wang, Yan Huang, Yuemin Nan, Xinhua Luo, Rongshu Shi, Yi Kang, Tao Han, Shiyan Chen, Kai Wang, Yunfeng Shan, Jiaping Li, Pingguo Liu, Zheng Lu, Jun Chen, Zhen Liu, Liaoyun Zhang, Li Yang, Jifang Sheng, Zhan Zeng, Yanyan Yu, Xiaoyuan Xu   +45 more
wiley   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Association of Melatonin Production with Seasonal Changes, Low Temperature, and Immuno-Responses in Hamsters

Molecules, 2018
Seasonal changes impact the melatonin production and immuno-activities in vertebrates. This is believed due to the photoperiodic alterations of the different seasons which impact the functions of pineal gland.
Xiaoying Xu, Xiaoyan Liu, Shuran Ma, Ya Xu, Ying Xu, Xiazhen Guo, Dekui Li   +6 more
doaj   +1 more source

Increased inflammation with crude E. coli LPS protects against acute leptospirosis in hamsters

Emerging Microbes and Infections, 2020
Leptospirosis is a worldwide zoonotic disease that causes acute kidney injury, liver disease, bleeding disorders, and even death. Treatment of the disease is largely dependent on the use of antibiotics, but recent studies on pathogenesis of leptospirosis
Wenlong Zhang, Xufeng Xie, Jiaqi Wang, Ning Song, Tianbao Lv, Dianjun Wu, Naisheng Zhang, Yongguo Cao   +7 more
doaj   +1 more source

Erste Hinweise auf Ozonido‐TMC‐Komplexe von Eisen und Kobalt

Angewandte Chemie, EarlyView.
Die Umsetzung der Eisen(II)‐Komplexe [(TMC)Fe(OTf)]BArF und [(D12‐TMC)Fe(OTf)]BArF sowie der Kobalt(II)‐Komplexe [(TMC)Co(OTf)]BArF und [(D12‐TMC)Co(X)]BArF (X = OTf, F) mit Ozon führt in einem 4:1‐Gemisch aus 2‐Me‐THF und THF bei Temperaturen bis −155°C zur Bildung von Ozonido‐ und Oxido‐Komplexen.
Stefan Schaub, Dennis Gerbig, Raffael C. Wende, Heike Hausmann, Jonathan Becker, Christian Würtele, Laura Senft, Ina Kellner, Gunasekaran Velmurugan, Marion Kerscher, Ivana Ivanović‐Burmazović, Peter Comba, Joshua Telser, Peter R. Schreiner, Siegfried Schindler   +14 more
wiley   +1 more source

Valganciclovir Inhibits Human Adenovirus Replication and Pathology in Permissive Immunosuppressed Female and Male Syrian Hamsters

Viruses, 2015
Adenovirus infections of immunocompromised pediatric hematopoietic stem cell transplant patients can develop into serious and often deadly multi-organ disease. There are no drugs approved for adenovirus infections.
Karoly Toth, Baoling Ying, Ann E. Tollefson, Jacqueline F. Spencer, Lata Balakrishnan, John E. Sagartz, Robert Mark L. Buller, William S. M. Wold   +7 more
doaj   +1 more source

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

Angewandte Chemie, EarlyView.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source