Results 61 to 70 of about 160,302 (312)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Current state of knowledge on the centrifugal visual system (including the pinealo-to-retinal connection) in mammals and its hypothesized role in circadian rhythms

Exploration of Neuroscience
The ubiquity of circadian rhythms in living organisms has generally been accepted by researchers over the last century. Indeed, morphology and molecular biology of the circadian clock were described during the last fifty years. This main biological clock
Viktória Vereczki, Katalin Köves, Ágnes Csáki   +2 more
doaj   +1 more source

Electron microscopic study of intestinal fat absorption in vitro from mixed micelles containing linolenic acid, monoolein, and bile salt

Journal of Lipid Research, 1966
Sacs and segments of everted hamster gut were incubated in vitro in solutions of mixed micelles (containing taurodeoxycholate, monoolein, and linolenic acid) for various periods and at different temperatures. The appearance of electron micrographs of the
Elliott W. Strauss
doaj   +1 more source

Clinical Characteristics of Patients Sensitized to Siberian Hamster

, 2016
The Siberian, Russian, or Dzungarian hamster (Phodopus sungorus) has gained great popularity with its introduction as a pet [1], probably because it is more sociable and smaller than other hamsters.
Torres, J. A., Vivanco Martínez, Fernando, Sanz Maroto, Aroa, Sastre Domínguez, Joaquín, Pastor Vargas, Carlos, De Las Heras Gozalo, Manuel   +5 more
core   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Substitution of cooked kidney beans or ground beef in hypercholesterolemic high fat diets reduces plasma and liver lipids in hamsters

Food Production, Processing and Nutrition, 2023
This study examined the physiological effects of replacing some of the casein with either a plant based, animal or combination of protein sources in a high-fat diet fed to golden Syrian hamsters.
John W. Finley, Darryl Holliday, Hyunsook Kim, Priscila Leal da Silva Alves, Dong-Yan Shao, Glenn Bartley, Wallace Yokoyama   +6 more
doaj   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

Advanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser, Haseeb Muhammad, Junaid Younas, Gillian Lovell, Bianca Migliori, Andreas Dengel, Sheraz Ahmed   +6 more
wiley   +1 more source

Lactobacillus Kefir M20 Adaptation to Bile Salts: A Novel Pathway for Cholesterol Reduction

Foods
(1) Background: This study investigated the impact of in vitro adaptations to acid and bile stress on the cholesterol-lowering activity of the probiotic Lactobacillus kefir M20.
Changlu Ma, Qichen Liu, Shuwen Zhang, Ailing Qu, Qing Liu, Jiaping Lv, Xiaoyang Pang   +6 more
doaj   +1 more source

Evaluation of surrogate animal models of melioidosis

Frontiers in Cellular and Infection Microbiology, 2010
Burkholderia pseudomallei is the Gram-negative bacterial pathogen responsible for the disease melioidosis. B. pseudomallei establishes disease in susceptible individuals through multiple routes of infection, all of which may proceed to a septicemic ...
Jonathan Mark Warawa
doaj   +1 more source

Molecular and Immunological Characterization of the First Allergenic Lipocalin in Hamster: the major allergen from Siberian hamster (Phodopus sungorus)

, 2014
The most frequent pet allergy is to cat and dog, but in recent years, it has become increasingly popular to have other pets, and the risk of exposure to new allergens is more prevalent.
Torres, José Alberto, Vivanco Martínez, Fernando, Sanz Maroto, Aroa, Pastor Vargas, Carlos, Heras, Manuel de las, Sastre, Joaquín   +5 more
core   +1 more source