Results 61 to 70 of about 115,928 (265)
Frontiers in Neuroscience, 2015 Knowledge of neuronal cell types in the mammalian retina is important for the understanding of human retinal disease and the advancement of sight-restoring technology, such as retinal prosthetic devices.
Ian L Jones +7 more
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Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
Effect of Thymectomy on Hamsters.
Experimental Biology and Medicine, 1965 SummaryThe effect of thymectomy at various ages on Syrian hamsters has been investigated. Forty-four per cent of the animals thymectomized and sham-operated at less than 24 hours did not survive the first 3 post-operative weeks. The remaining animals, however, appeared as healthy and survived as long as their control littermates. A mild wasting disease
R A, ROOSA, D B, WILSON, V, DEFENDI
openaire +2 more sources
Advanced Science, EarlyView.SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao +15 more
wiley +1 more source
Preclinical Models of Oropouche Virus Infection and Disease
PathogensOropouche virus (OROV) is an emerging and underreported arbovirus with dengue-like symptoms confounding diagnosis. OROV is also neuroinvasive, with a small number of cases presenting severe neurological symptoms.
Daniel Morley +2 more
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Advanced Science, EarlyView.A multi‐epitope digital surface‐enhanced Raman spectroscopy framework enables epitope‐resolved immunoprofiling by integrating bispecific antibody fragments with spectrally encoded nanotags. This approach decouples binding events into independent digital channels, allowing structure‐aware antigen analysis.
Jing Wang +4 more
wiley +1 more source
Molecules, 2018 Seasonal changes impact the melatonin production and immuno-activities in vertebrates. This is believed due to the photoperiodic alterations of the different seasons which impact the functions of pineal gland.
Xiaoying Xu +6 more
doaj +1 more source
Increased inflammation with crude E. coli LPS protects against acute leptospirosis in hamsters
Emerging Microbes and Infections, 2020 Leptospirosis is a worldwide zoonotic disease that causes acute kidney injury, liver disease, bleeding disorders, and even death. Treatment of the disease is largely dependent on the use of antibiotics, but recent studies on pathogenesis of leptospirosis
Wenlong Zhang +7 more
doaj +1 more source
Amyloidosis in Hamsters with Leishmaniasis.
Experimental Biology and Medicine, 1946 SummaryForty-six days after successful inoculation of L. donovani into hamsters, there appeared edema associated with amyloidosis. There was marked anasarca at 60 and 77 days after infection with extensive deposition of amyloid in the glomeruli and the adrenal cortex. The hypoalbuminemia, which coincided with the edema and a proteinuria, is believed to
A. Gellhorn +3 more
openaire +2 more sources
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source