Results 61 to 70 of about 8,144 (197)

Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects

ChemMedChem, Volume 20, Issue 21, November 6, 2025.
Pyrrolidine‐type naphthalene‐2‐acetamide compound 5i inhibits Kelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2) protein–protein interaction by binding to the Keap1‐DC domain; it subsequently activates intracellular Nrf2 and induces Nrf2‐target genes.
Daisuke Yasuda, Kai Toyoshima, Koujin Kojima, Hanako Ishida, Kazuma Kaitoh, Riyo Imamura, Kayoko Kanamitsu, Hirotatsu Kojima, Megumi Funakoshi‐Tago, Masanori Osawa, Tomoyuki Ohe, Tomoya Hirano   +11 more
wiley   +1 more source

The effect of explicit instruction and error correction on learners’ grammatical accuracy in the case of japanese learners of English as a second language [PDF]

, 2017
Este estudio afirma que la instrucción explicita (EI) con la corrección de error explicito (EEC) pueden ser eficaces para adquirir elementos lingüísticos que no se hayan enseñado lo suficiente y que mayormente expresen significado léxico. Por otra parte,
Kondo, Takako, Shirahata, Tomohiko, Suda, Koji, Yokota, Hideki   +3 more
core  

Diet‐Faeces Trophic Discrimination Factor and Gut Passage Time of an Aotearoa New Zealand Insectivorous Bat, Chalinolobus tuberculatus, Determined via Controlled Feeding Experiment

Journal of Animal Physiology and Animal Nutrition, Volume 109, Issue 6, Page 1361-1367, November 2025.
ABSTRACT Studying bat diet is challenging due to their rarity, cryptic nature, nocturnal habits, and protected status. Stable isotope analysis of bat faeces offers a promising noninvasive and nonlethal method to understand their trophic interactions.
Lola Nomblot, Kerry M. Borkin, Sarah J. Bury, Amandine Sabadel   +3 more
wiley   +1 more source

A 2‐Min Cytomegalovirus (CMV) Awareness Video Improves Pregnant Women's Knowledge and Planned Adherence to Hygiene Precautions

Australian and New Zealand Journal of Obstetrics and Gynaecology, Volume 65, Issue 5, Page 662-670, October 2025.
ABSTRACT Introduction Congenital cytomegalovirus (cCMV) is a leading infectious cause of life‐long neurodevelopmental disabilities, but public awareness of CMV is low. This study evaluated a short educational video on cCMV for its acceptability and impact on pregnant women's knowledge and planned hygiene adherence.
Tanya Tripathi, Jotara Watson, Hayley Smithers‐Sheedy, Kath Swinburn, Natalia Rode, Emma Waight, Annabel Webb, Natasha E. Holmes, Hanako Stump, Antonia Shand, Lisa Hui   +10 more
wiley   +1 more source

Tubulovillous adenoma with high-grade dysplasia of the vulva harboring high tumor mutational burden and cancer-associated mutations: a case report

Diagnostic Pathology, 2022
Background Vulvar cancer is a rare disease, accounting for approximately 5% of gynecological malignancies. Primary adenocarcinoma of intestinal-type of the vulva or its precancerous lesion is extremely rare, and details regarding its origin, evolution ...
Hanako Sato, Kosuke Murakami, Tomoyuki Otani, Noriomi Matsumura   +3 more
doaj   +1 more source

Psychiatric‐onset neuronal intranuclear inclusion disease in a psychiatry‐based dementia‐enriched cohort in Japan

Psychiatry and Clinical Neurosciences, Volume 79, Issue 9, Page 561-571, September 2025.
Aim A GGC repeat expansion in the 5′ untranslated region of NOTCH2NLC is a genetic cause of Neuronal Intranuclear Inclusion Disease (NIID) that exhibits cognitive, motor, and autonomic dysfunction. Our objective is to determine whether there are undiagnosed NIID cases in a psychiatry‐based dementia‐enriched cohort and to identify their clinical ...
Tesshin Miyamoto, Kohji Mori, Shoshin Akamine, Shizuko Kondo, Shiho Gotoh, Ryota Uozumi, Sumiyo Umeda, Hanako Koguchi‐Yoshioka, Satoshi Nojima, Daiki Taomoto, Yuto Satake, Takashi Suehiro, Hideki Kanemoto, Kenji Yoshiyama, Takashi Morihara, Manabu Ikeda   +15 more
wiley   +1 more source

VERBA BEROBJEK GANDA BAHASA JEPANG [PDF]

, 2017
Penelitian ini bertujuan mendeskripsikan kata kerja yang melibatkan objek ganda, yaitu kata kerja ageru ‘memberi’, oshieru ‘mengajar/ajar’, kureru ‘memberi’, dan kau ‘membeli’, sehingga memunculkan objek tak langsung dalam struktur kalimat bahasa ...
Aryani, Made Ratna Dian
core  

Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T‐Cell Leukemia/Lymphoma

Cancer Science, Volume 116, Issue 8, Page 2163-2175, August 2025.
UMAP projection of CD4 T cells from ATLL patients specified a CD48‐deficient cluster, in which YY1 and EZH2 are upregulated. ABSTRACT The clinical and genetic presentation of adult T‐cell leukemia/lymphoma (ATLL) ranges from indolent to aggressive, making it difficult to identify common therapeutic targets.
Takuya Shimizu, Takero Shindo, Hanako Ogawa, Kaori Teranaka, Akira Watanabe, Akifumi Takaori‐Kondo   +5 more
wiley   +1 more source

Moraxella osloensis: an unusual cause of central venous catheter infection in a cancer patient

International Journal of General Medicine, 2012
Yoshiro Hadano,1 Kenta Ito,1 Jun Suzuki,1 Ichiro Kawamura,1 Hanako Kurai,1 Kiyofumi Ohkusu21Division of Infectious Diseases, Shizuoka Cancer Center, Shizuoka; 2Department of Microbiology, Graduate Medical School of Medicine, Gifu University, Gifu ...
Hadano Y, Ito K, Suzuki J, Kawamura I, Kurai H, Ohkusu K   +5 more
doaj  

Plant ADH1 promoter acts as an H3K27me3‐associated hyper‐long cold‐responsive promoter

The Plant Journal, Volume 122, Issue 5, June 2025.
Significance Statement A genome‐wide search identified Arabidopsis halleri ALCOHOL DEHYDROGENASE 1 (ADH1) promoter as a responder that exhibits a week‐scale environmental response (WER). In response to cold exposure, the endogenous ADH1 promoter showed WER in terms of H3K27me3 accumulation.
Hanako Shimizu, Haruki Nishio, Hiroshi Kudoh   +2 more
wiley   +1 more source