Results 111 to 120 of about 14,131,417 (354)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Are encalves amenities? An empricial investigation in the Southwest United States. [PDF]

open access: yes
The role of linguistic enclaves in wage determination is investigated for immigrants and non-immigrants. It is hypothesized that enclaves could affect wages positively as an aid to immigrant adjustment, or negatively as an amenity that minority language ...
Michael Hand
core  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Guest Editorial: One Size Does Not Fit All, One Critique Does Not Fit All Schools of Education

open access: yes, 2008
Many years ago, Dr. Martin Luther King reminded us that skin tone should never be a factor to judge an individual, but rather the content of the individual’s character is the issue to be considered.
Hand, David, Otto, Patrick
core  

Uppercase and lowercase computer printout increases readability [PDF]

open access: yes, 1965
Print chain of 120 characters facilitates production of computer printout in both uppercase and lowercase characters.
Hand, W. W., Jonsberg, M. B.
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

The Promise at Hand [PDF]

open access: yes, 1992
Based on a former RWJF vice president's seminar, gives an overview of the history and role of foundations in U.S. society, their uncertain status as social institutions, and their regulatory history.
Terrance Keenan
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Editorial

open access: yesIndialogs: Spanish Journal of India Studies, 2017
Felicity Hand
doaj   +1 more source

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