Results 61 to 70 of about 850,931 (288)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Heteroduplex analysis of tra delta f' plasmids and the mechanism of their formation [PDF]

open access: yes, 1977
Four tra delta FargG+ plasmids, derived from matings between Hfr AB312 and a recA recipient, have been shown to have deletions of at least 50% of the F genome, including the region in which the tra genes map.
Clark, Alvin J.   +2 more
core   +1 more source

Soft Pomerons and the Forward LHC Data

open access: yes, 2018
Recent data from LHC13 by the TOTEM Collaboration on $\sigma_{tot}$ and $\rho$ have indicated disagreement with all the Pomeron model predictions by the COMPETE Collaboration (2002).
Broilo, M., Luna, E. G. S., Menon, M. J.
core   +1 more source

EEG–fMRI mapping of asymmetrical delta activity in a patient with refractory epilepsy is concordant with the epileptogenic region determined by intracranial EEG [PDF]

open access: yes, 2006
We studied a patient with refractory focal epilepsy using continuous EEG-correlated fMRI. Seizures were characterized by head turning to the left and clonic jerking of the left arm, suggesting a right frontal epileptogenic region.
Duncan, J.S.   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

USING COMPUTER-GAMING TESTS TO EVALUATE HAND SIMPLE REACTION TIME TO VISUAL STIMULUS

open access: yesSport şi Societate, 2016
Aim. The research aimed to identify the hand reaction time to visual stimulus depending on laterality, by using the computer-gaming test. The computer technology can be applied to improve the reaction time of both dominant and non-dominant segment ...
Dana Badau   +4 more
doaj  

The Prevalence of Left-Handedness Is Higher Among Individuals With Developmental Coordination Disorder Than in the General Population

open access: yesFrontiers in Psychology, 2018
Many medical, psychiatric and neurological conditions have been characterized by a high prevalence of left-handedness or mixed-handedness. Several studies have indicated an elevated frequency of left-handedness in children with Developmental Coordination
Monica Darvik   +2 more
doaj   +1 more source

Investigating bimanual coordination in dominant and non-dominant virtual hands

open access: yesLaterality: Asymmetries of Body, Brain and Cognition, 2008
A bias in attention towards the dominant hand has been cited as a possible factor in the lateralisation of human bimanual coordination (Peters, 1981). A mirror was placed between the hands of 18 dextral participants performing rhythmic anti-phase movements. This set-up gave the appearance of a reflected virtual hand (moving in time with the un-occluded
Buckingham, Gavin, Carey, David P.
openaire   +4 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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