Results 51 to 60 of about 241,424 (301)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Upper Limb Nerve Injuries in Sport [PDF]

, 2018
Nerve injury in sports is not very frequent. According to the report of the Japanese Athletic Association in 1971, peripheral nerve injuries accounted for only 0.3% of sports injuries. Among all peripheral nerve injuries treated in their centre within 18
Josephine Wing-yuk Ip, Jennette Sze-yan Chan, Ip, WY, Chan, SYJ   +3 more
core   +1 more source

Does a Novel Gamification Approach Improve Hand Function in Patients Undergoing Rehabilitation? A Mono-Centric Randomized Controlled Trial

Applied Sciences
Background: Gamification is a promising approach to support rehabilitation, but implementing new devices after hand surgery (HS) faces challenges, especially in patient motivation and compliance.
Heithem Ben Abdallah, Janina Tennler, Christine Seelmann, Viola Haverkamp, Christian Schmitz, Heinz-Herbert Homann, Tobias Ohmann   +6 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Nail Bed Reconstruction Using Synthetic Matrix: A Case Series

Journal of Hand Surgery Global Online
Injuries to fingertips are one of the most common hand injuries treated in medical settings. Traditional treatment options often have disadvantages, such as increased risk of infection, high cost, and donor-site morbidity.
Devin C. Potter, MD, Caleb A. LaVigne, MD, Haley D. Puckett, MD, Gary M. Lourie, MD   +3 more
doaj   +1 more source

Specificities of hand trauma in agriculture [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. Hand injuries in agriculture are characterized by massive destruction of all tissues, frequent amputations of finger, hand and often the whole extremity. These injuries are mutilant and can cause death.
Nikolić Jelena, Janjić Zlata
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Acute Mallet Finger Injuries—A Review [PDF]

, 2022
Acute disruptions of the terminal extensor tendon are common and can result in significant dysfunction if not recognized and treated appropriately. This article provides a topical review of the contemporary literature concerning acute mallet finger ...
Graham, DJ, Lawson, RD, Sivakumar, BS, Ledgard, JP   +3 more
core   +1 more source

Grinder Injury of the Hand: A Rare but Devastating Occupational Hazard

The Surgery Journal, 2021
Food handlers and workers are exposed to several occupational hazards not frequented by the general population. Grinder injuries of the hand present a devastating consequence of industrial food processing that is infrequently described.
Tushar Patial, Rajinder K. Mittal, Ramneesh Garg, Sheerin Shah, Amandeep Kaur   +4 more
doaj   +1 more source