Results 61 to 70 of about 5,746,406 (334)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Epidemiology of isolated hand injuries in the United Arab Emirates

World Journal of Orthopaedics, 2016
AIM To provide suggestions for hand injury prevention by study the demography and risk factors of casualties suffering from isolated hand injuries. METHODS All trauma patients with isolated hand injuries who were admitted to Al Ain Hospital for more than
M. Grivna, H. Eid, F. Abu-Zidan
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Acute injuries in student circus artists with regard to gender specific differences [PDF]

, 2012
Purpose: Student circus artists train as both artists and athletes with their bodies holding the key to professional success. The daily training load of student circus artists is often associated with maximum physical and psychological stress with ...
Groneberg, Jan David Alexander, Koch, Franziska, McCormack, Moira, Wanke, Alice, Wanke, Eileen M.   +4 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Does a Novel Gamification Approach Improve Hand Function in Patients Undergoing Rehabilitation? A Mono-Centric Randomized Controlled Trial

Applied Sciences
Background: Gamification is a promising approach to support rehabilitation, but implementing new devices after hand surgery (HS) faces challenges, especially in patient motivation and compliance.
Heithem Ben Abdallah, Janina Tennler, Christine Seelmann, Viola Haverkamp, Christian Schmitz, Heinz-Herbert Homann, Tobias Ohmann   +6 more
doaj   +1 more source

Work-related hand injuries: type, location, cause, mechanism and severity in a tertiary hospital [PDF]

, 2012
Introduction: Work-Related Hand Injuries (WRHIs) may result in disability and diminished productivity and cause economic impacts not only to the individual, worker’s families and industries, but to the local community as well.
Alhusuny, Ameer, Ariffin, Ahmad Azuhairi, Arumugam, Manohar, Gyanchand Rampal, Lekhraj Rampal, M. Y., Adon   +4 more
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Nail Bed Reconstruction Using Synthetic Matrix: A Case Series

Journal of Hand Surgery Global Online
Injuries to fingertips are one of the most common hand injuries treated in medical settings. Traditional treatment options often have disadvantages, such as increased risk of infection, high cost, and donor-site morbidity.
Devin C. Potter, MD, Caleb A. LaVigne, MD, Haley D. Puckett, MD, Gary M. Lourie, MD   +3 more
doaj   +1 more source

Meat Grinder Injury to the Hand: Serial Cases [PDF]

, 2012
Introduction.Although meat grinder injury to the hand is not a common case, it causes a wide spectrum of injuries that result not only in tremendous physical and emotional pain but also substantial economic impact as well.Case presentation.Three ...
Lubis, N. R. (Nur)
core