Results 61 to 70 of about 822,233 (304)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Does a Novel Gamification Approach Improve Hand Function in Patients Undergoing Rehabilitation? A Mono-Centric Randomized Controlled Trial

Applied Sciences
Background: Gamification is a promising approach to support rehabilitation, but implementing new devices after hand surgery (HS) faces challenges, especially in patient motivation and compliance.
Heithem Ben Abdallah, Janina Tennler, Christine Seelmann, Viola Haverkamp, Christian Schmitz, Heinz-Herbert Homann, Tobias Ohmann   +6 more
doaj   +1 more source

Work-related hand injuries: type, location, cause, mechanism and severity in a tertiary hospital [PDF]

, 2012
Introduction: Work-Related Hand Injuries (WRHIs) may result in disability and diminished productivity and cause economic impacts not only to the individual, worker’s families and industries, but to the local community as well.
Alhusuny, Ameer, Ariffin, Ahmad Azuhairi, Arumugam, Manohar, Gyanchand Rampal, Lekhraj Rampal, M. Y., Adon   +4 more
core  

An empirical analysis of potential cyclist injuries and cycling outfit comfort [PDF]

, 2019
This study investigated the relationship between pain/injury and training characteristics in cyclists. In addition, ergonomic wear comfort of their garments was investigated. A total of 94 complete questionnaire responses were analyzed.
Ciocci, Maria-Cristina, Malengier, Benny, Tesfaye, Tamrat, Teyeme, Yetanawork Wubneh, Van Langenhove, Lieva, Vasile, Simona-Ileana   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Nail Bed Reconstruction Using Synthetic Matrix: A Case Series

Journal of Hand Surgery Global Online
Injuries to fingertips are one of the most common hand injuries treated in medical settings. Traditional treatment options often have disadvantages, such as increased risk of infection, high cost, and donor-site morbidity.
Devin C. Potter, MD, Caleb A. LaVigne, MD, Haley D. Puckett, MD, Gary M. Lourie, MD   +3 more
doaj   +1 more source

Meat Grinder Injury to the Hand: Serial Cases [PDF]

, 2012
Introduction.Although meat grinder injury to the hand is not a common case, it causes a wide spectrum of injuries that result not only in tremendous physical and emotional pain but also substantial economic impact as well.Case presentation.Three ...
Lubis, N. R. (Nur)
core  

Injuries in the Chinese Arena Football League: American Versus Chinese Players. [PDF]

, 2018
Background: Arena football is an indoor version of American football played in indoor arenas on a smaller field with 8 players per team. Only 1 study has evaluated injury rates in arena football, and no study had compared 2 distinct cohorts of players ...
Chen, Shiyi, Chen, Tianwu, Feldman, Michael, Gillespie, Gunnar, Rubenstein, David, Singer, Scott, Wetzler, Austin, Wetzler, Merrick   +7 more
core   +2 more sources

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source