Results 51 to 60 of about 750,742 (319)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differences in the Outcomes of Early Active Mobilization Following Flexor Tendon Repair Between Zone 1 and Distal Zone 2 Injuries

Journal of Hand Surgery Global Online
Purpose: Complete release of the A4 pulley is recommended for flexor tendon repair to allow smooth tendon excursion, provided the proximal sheath is mostly intact.
Koji Moriya, MD, Yutaka Maki, MD, Hisao Koda, MD, Masahiro Odagiri, OT, Shota Matsuzawa, OT, Naoto Tsubokawa, MD   +5 more
doaj   +1 more source

Single incision thenar muscle reconstruction using the free functional pronator quadratus flap

BMC Surgery, 2021
Background Injuries to the thenar muscle mass or the thenar branch of the median nerve and resulting loss of thumb opposition lead to a massive impairment of hand function. For decades, reconstructive approaches were based on tendon transfers. To broaden
Martin Aman, Arne H. Boecker, Mirjam Thielen, Camillo T. Mueller, Amir K. Bigdeli, Ulrich Kneser, Leila Harhaus   +6 more
doaj   +1 more source

RECONSTRUCTIVE SURGERY OF THE HAND [PDF]

Journal of the American Medical Association, 1919
One of the most perplexing problems that were presented to the orthopedic surgeon during the war was the restoration of function in injuries of the hand. Each case presented many difficulties rather than a single problem. Complete restoration of function, or as nearly complete restoration as possible, is essential before the full duty of the surgeon to
openaire   +1 more source

Outcome of a Hand Orthosis and Hand Therapy for Carpometacarpal Osteoarthritis in Daily Practice: A Prospective Cohort Study

, 2018
PURPOSE: Initial treatment for symptomatic carpometacarpal (CMC) osteoarthritis (OA) of the thumb is usually nonsurgical. However, evidence on the effect of a hand orthosis and hand therapy for mid- and long-term results is limited, and it is unknown how
Slijper, Harm, Feitz, R, Feitz, R; id_orcid, Wouters, Robbert, Wouters, Robbert; id_orcid, Selles, R.W., Wouters, R.M., Spekreijse, K.R., Spekreijse, Kim, Tsehaie, Jonathan, Slijper, H.P., Selles, Ruud, Hovius, S.E.R., Feitz, R., Hovius, Steven, Tsehaie, J., Selles, Ruud; id_orcid   +16 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Evaluation of an International Classification of Functioning, Disability and Health-based rehabilitation for thermal burn injuries: a prospective non-randomized design

Trials, 2019
Background Severe burn injuries result in relevant restrictions of physical capacity as well as psychological and social integrity and require a specialized rehabilitation.
Hubert Neubauer, Annette Stolle, Sabine Ripper, Felix Klimitz, Hans Ziegenthaler, Mareike Strupat, Ulrich Kneser, Leila Harhaus   +7 more
doaj   +1 more source

Robotic Microsurgery Training for Robot Assisted Reconstructive Surgery [PDF]

, 2019
Purpose: Recent advances in robotic surgery have affected not only surgery for visceral organs but also head and neck cancer surgery and microsurgery. The authors intended to analyze and share experience gained from performing microanastomosis training ...
신동우, 이원재, 홍종원, 이동원   +3 more
core   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Biomechanical Analysis of a New Eight-Strand Suture for Flexor Tendon Repair

Indian Journal of Plastic Surgery, 2022
Background The placement of multistrand sutures during flexor tendon repair requires complicated surgical skills; such suturing is difficult. We developed a new, simpler eight-strand suture, which we term the Yoshizu cross-lock.
Koji Moriya, Yutaka Maki, Hisao Koda, Naoto Tsubokawa   +3 more
doaj   +1 more source