Results 41 to 50 of about 693,025 (273)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Analysis of the Correlation Between Majority Voting Error and the Diversity Measures in Multiple Classifier Systems [PDF]
, 2001 Combining classifiers by majority voting (MV) has recently emerged as an effective way of improving performance of individual classifiers. However, the usefulness of applying MV is not always observed and is subject to distribution of classification ...
Ruta, Dymitr, Gabrys, Bogdan
core +6 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
SOIL CLASSIFIERS NEWSLETTER [PDF]
, 2016 This newsletter from the Soil Classifiers Advisory Council gives information about the Council including professional licenses for soil classifiers, office hours and state holidays, council members and staff and online ...
South Carolina Soil Classifiers Advisory Council
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Choice of handshape and classifier type in placement verbs in American Sign Language
Open LinguisticsThis study investigates choice of classifier handshape in the placement verbs MOVE and PUT in American Sign Language (ASL), analyzing data from two deaf ASL signers describing placement events elicited via a semi-structured task.
Frederiksen Anne Therese
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Online multiple people tracking-by-detection in crowded scenes [PDF]
Journal of Advances in Computer Engineering and Technology, 2015 Multiple people detection and tracking is a challenging task in real-world crowded scenes. In this paper, we have presented an online multiple people tracking-by-detection approach with a single camera.
Sahar Rahmatian, Reza Safabakhsh
doaj
IEEE Access, 2019 Credit scoring is an efficient tool in handling the information asymmetry of peer-to-peer (P2P) lending. Credit scoring models are typically built only with the accepted applicants, which may cause sample bias and further hinder the predictive ...
Yufei Xia
doaj +1 more source