Results 51 to 60 of about 21,772 (300)

Adaptively Weighted Large Margin Classifiers

open access: yes, 2013
Large margin classifiers have been shown to be very useful in many applications. The Support Vector Machine is a canonical example of large margin classifiers.
Liu, Yufeng, Wu, Yichao
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Choice of handshape and classifier type in placement verbs in American Sign Language

open access: yesOpen Linguistics
This study investigates choice of classifier handshape in the placement verbs MOVE and PUT in American Sign Language (ASL), analyzing data from two deaf ASL signers describing placement events elicited via a semi-structured task.
Frederiksen Anne Therese
doaj   +1 more source

An Improved Algorithm for Bayes Classifier to Handle Correlated Attributes

open access: yesInternational Journal of Computer Applications, 2013
Classification can be defined as a target function which maps attribute value of objects to predefined class. One objective is to divide the objects into proper group and other objective is to predict the class of unknown records. Bayesian classifier classifies and predicts the class of objects on the basis of posterior probability based on some prior ...
Kshitij Pathak, Sharmishtha Panagare
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

A Novel Reject Inference Model Using Outlier Detection and Gradient Boosting Technique in Peer-to-Peer Lending

open access: yesIEEE Access, 2019
Credit scoring is an efficient tool in handling the information asymmetry of peer-to-peer (P2P) lending. Credit scoring models are typically built only with the accepted applicants, which may cause sample bias and further hinder the predictive ...
Yufei Xia
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Online multiple people tracking-by-detection in crowded scenes [PDF]

open access: yesJournal of Advances in Computer Engineering and Technology, 2015
Multiple people detection and tracking is a challenging task in real-world crowded scenes. In this paper, we have presented an online multiple people tracking-by-detection approach with a single camera.
Sahar Rahmatian, Reza Safabakhsh
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy