Results 101 to 110 of about 364,270 (312)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Flight evaluation of the M2-F3 lifting body handling qualities at Mach numbers from 0.30 to 1.61 [PDF]
Percentage distributions of 423 pilot ratings obtained from 27 flights are used to indicate the general level of handling qualities of the M2-F3 lifting body.
Dana, W. H., Kempel, R. W., Sim, A. G.
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Development and application of an atmospheric turbulence model for use in flight simulators in flight simulators [PDF]
The influence of simulated turbulence on aircraft handling qualities was investigated. Pilot opinion of the handling qualities of a light general aviation aircraft were evaluated in a motion-base simulator using a simulated turbulence environment.
Jacobson, I. D., Joshi, D. S.
core +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
A pilot in the loop analysis of helicopter acceleration/deceleration maneuvers [PDF]
Helicopter flight acceleration/deceleration maneuvers are quantified and put to use in the fields of handling qualities, flight training and evaluation of simulator fidelity.
Heffley, R. K.
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Status quo of acute severe trauma and rescue progress
Huli yanjiu, 2005 it analyzed the status quo of acute severe trauma, summarized the rescue principles of patients with severe trauma, principles of handling of its complications and new nursing viewpoints of them.
赵桂英, 王宁, 李金焕
doaj
Effects of simulated turbulence on aircraft handling qualities [PDF]
The influence of simulated turbulence on aircraft handling qualities is presented. Pilot opinions of the handling qualities of a light general aviation aircraft were evaluated in a motion-base simulator using a simulated turbulence environment.
Jacobson, I. D., Joshi, D. S.
core +1 more source