Results 91 to 100 of about 642,928 (316)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Intelligent mobility control of a hybrid electric off-road vehicle with individual wheel control [PDF]

open access: yes, 2003
This work focuses on the potential benefits that can be gained from the use of Individual Wheel Control on a large off-road vehicle. The vehicle concerned is a theoretical, six-wheel drive, off-road Hybrid-Electric Vehicle based on an existing ...
Jackson, Andrew Edward
core  

Baseband Data Handling System Using LEON3FT Processor [PDF]

open access: yes, 2016
The data handling system is used to receive the data from the payloads of the satellite and format the data into suitable form so that it can be successfully received at the ground station.
, Arun. N, Dr. S Revathi
core   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Development of a reconfigurable pallet system for a robotic cell

open access: yesMATEC Web of Conferences, 2018
Advanced manufacturing systems allow rapid changes of production processes by means of reconfigurability providing mass customisation of products with high productivity, quality and low costs.
Koekemoer Martin, Gorlach Igor
doaj   +1 more source

Using mobility and exception handling to achieve mobile agents that survive server crash failures [PDF]

open access: yes, 2005
Mobile agent technology, when designed and used effectively, can minimize bandwidth consumption and autonomously provide a snapshot of the current context of a distributed system. Protecting mobile agents from server crashes is a challenging issue, since
Pears, Simon
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Analysis on Pipe Handling System for Onshore Drilling Rig

open access: yesShiyou jixie, 2016
Based on the development status of domestic and foreign pipe handling systems for onshore drilling rigs, technical analysis is conducted on the suspension type, push-support type and hybrid pipe handling systems.
Yang Haigang   +5 more
doaj  

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